The Spectrum of Mesenchymal Skin Neoplasms Reflected by the New WHO Classification

Abstract

Mesenchymal tumors are a heterogeneous group of tumors often arising in the skin and soft tissue. The tumors have been reclassified by the WHO in 2002. Benign mesenchymal tumors are about a hundred times more frequent than malignant mesenchymal tumors. Clinically, mesenchymal tumors often present as skin-colored nodes. Overall, elderly persons are more affected than younger individuals. The etiology is often unknown, sometimes there is an association with insults such as radiation, scars, or lymphedematous or venous stasis. Whereas some years ago a wide excision with a margin of 3–5 cm was performed for malignant variants, today micrographic surgery is preferred, as it can avoid mutilating procedures. Early detection and removal is critical since mesenchymal skin tumors often cannot be cured by radiation or chemotherapy.

Primary undifferentiated pleomorphic sarcoma of the thyroid

“…Undifferentiated pleomorphic sarcoma is extremely rare in the head and neck region, which has been reported in parotid gland, mandible and eyelid, and only accounts for about 3% of all undifferentiated pleomorphic sarcomas. [ 15 ] Clinically, UPS-T has no specific signs and presents with painless large mass and can be accompanied by cough, dyspnea, and dysphagia in some patients. [ 16 ] ATC is an extremely rare malignancy of thyroid, which most commonly presents with a similar clinical manifestation to UPS-T. [ 16 ] Therefore, it is difficult to differentiate UPS-T from ATC by clinical features.…”

Aggressively progressing primary undifferentiated pleomorphic sarcoma in the eyelid

“…In the head and neck, undifferentiated pleomorphic sarcoma is extremely rare and accounts for only about 3% of all undifferentiated pleomorphic sarcomas. [7] After the 2002 WHO classification, there has been few articles published about a primary undifferentiated pleomorphic sarcoma of the eyelid. [1–3] Hence, our report represents an extremely rare case of a rapidly progressing primary undifferentiated pleomorphic sarcoma of the eyelid after 2002 and 2013 WHO classification.…”

Histopatología, inmunohistoquímica y metástasis en pacientes con carcinoma basocelular

“…El CBC presenta características comunes entre los subtipos con presencia de nidos de células pequeñas, basaloides, de núcleos hipercromáticos, con empalizada periférica y escaso citoplasma, rodeado por un estroma con retracción artefactual, el estroma del tumor es fibromixoide. En algunos casos se ha observado hendiduras de colesterol cuando el CBC está asociado a microtraumatismo local (Vea la Figura 1 y 2) [14,15]. La OMS clasifica al CBC en subtipos morfológicos de acuerdo al riesgo de recurrencia, en carcinomas de bajo y de alto riesgo, de estos hallazgos histopatológicos se basa el médico clínico para el tratamiento más adecuado en beneficio del paciente [14].…”

“…En algunos casos se ha observado hendiduras de colesterol cuando el CBC está asociado a microtraumatismo local (Vea la Figura 1 y 2) [14,15]. La OMS clasifica al CBC en subtipos morfológicos de acuerdo al riesgo de recurrencia, en carcinomas de bajo y de alto riesgo, de estos hallazgos histopatológicos se basa el médico clínico para el tratamiento más adecuado en beneficio del paciente [14].…”