The spectrum of pulmonary amyloidosis

Riehani, Anas; Soubani, Ayman O.

doi:10.1016/j.rmed.2023.107407

Cited by 9 publications

(4 citation statements)

References 113 publications

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“…Definitive diagnosis of TA typically depends on bronchoscopy biopsy coupled with Congo red staining. 1,8,17 The present case was diagnosed as TA accompanied with asthma. There were typical characteristics of CT scan and pathological changes that supported a clear diagnosis of TA.…”

Section: Discussionmentioning

confidence: 69%

“…Definitive diagnosis of TA typically depends on bronchoscopy biopsy coupled with Congo red staining. 1 , 8 , 17 …”

Section: Discussionmentioning

confidence: 99%

“…Repeated bronchoscopic treatment, including local resection, laser therapy, stent placement, and radiation therapy, is considered a safer and better option. 1 , 17 , 21 The 5-year survival rate of patients with TA range between 30% and 50%. 1 The present patient’s symptoms were improved when subjected to active asthma treatment.…”

Section: Discussionmentioning

confidence: 99%

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Tracheobronchial Amyloidosis Accompanied with Asthma: A Case Report and a Mini-Review

Sun,

Liu,

et al. 2023

JAA

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Tracheobronchial amyloidosis is a rare disease characterized by amyloid deposits on the tracheal and bronchial tissue. Patients with tracheobronchial amyloidosis are asymptomatic or exhibit symptoms, such as chronic wheezing, dyspnea, and cough, that are common manifestations of other disorders, including asthma. A bronchoscopic tissue biopsy using Congo red staining is the key standard for diagnosing tracheobronchial amyloidosis. Treatment strategies vary depending on the degree of airway obstruction. If the obstruction is significant and the patient is symptomatic, repeated bronchoscopic treatment, including local resection, laser therapy, stent placement, and radiation therapy, is considered a safer and better option. It is often misdiagnosed as asthma, but cases of tracheobronchial amyloidosis accompanied with asthma have not been reported. We report a case of intermittent wheezing, cough for 33 years, and shortness of breath on exertion for 7 years, which had aggravated in the previous 22 days. A pulmonary examination revealed diffuse wheezing. Pulmonary function testing revealed an obstructive ventilation dysfunction. Computerized tomography (CT) imaging revealed circumferential and irregular thickening of the tracheobronchial wall tissue with calcification and atelectasis of the right middle and lower lobe of the lung. Bronchoscopy revealed diffuse thickening of the mucosa of the trachea and bilateral main bronchi, with multiple nodular protuberances and relatively narrow lumens. The bronchial biopsies revealed massive amyloid deposits under the bronchial mucosa. The deposits exhibited a green birefringence under crossed polarized light after Congo red positive staining. The patient received standard treatment for asthma, and remains in good general condition without wheezing. It is not difficult to distinguish tracheobronchial amyloidosis through chest CT examination for patients with wheezing as long as this disease was considered. It was interesting that we present a rarer case of patient with tracheobronchial amyloidosis accompanied with asthma which both can cause symptoms such as wheezing.

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Section: Discussionmentioning

confidence: 69%

“…Definitive diagnosis of TA typically depends on bronchoscopy biopsy coupled with Congo red staining. 1 , 8 , 17 …”

Section: Discussionmentioning

confidence: 99%

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Tracheobronchial Amyloidosis Accompanied with Asthma: A Case Report and a Mini-Review

Sun,

Liu,

et al. 2023

JAA

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“…The amyloid proteins can be derived from serum proteins or produced locally, are unable to be metabolically cleared, leading to cell death at the corresponding site, destruction of tissue structure and function, subsequent organ function impairment, and ultimately, related organ dysfunction (Riehani and Soubani 2023 ). Nasopharyngeal amyloidoma is a distinct entity characterized by the presence of amyloid deposition within the nasopharynx, without evidence of systemic amyloidosis (Desai et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal amyloidoma: report of three cases and review of the literature

Zuo,

Du,

Chen

2024

J Cancer Res Clin Oncol

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Background Nasopharyngeal amyloidoma is a rare, locally aggressive tumor that has been reported in the English literature in only 38 cases to date, most of which were in the form of case reports. The present study was aimed to summarize the characteristics of this rare tumor, with the goal of providing new insights for diagnosis and treatment. Materials and methods We report three cases of nasopharyngeal amyloidoma diagnosed in our hospital following comprehensive medical examination and review the current literature on all cases of nasopharyngeal amyloidoma from PubMed. The journey of nasopharyngeal amyloidoma, including presentation, diagnostics, surgeries, and follow-up was outlined. Results None of the three patients had systemic amyloidosis. CT and nasal endoscopy showed irregular masses obstructing the nasopharyngeal cavity. Congo red staining confirmed the deposition of amyloid, and immunohistochemical analysis showed that the amyloid deposition was the AL light chain type. Through literature review, we found that nasopharyngeal amyloidoma most commonly occurred in individuals over the age of 40, patients usually had a good prognosis after complete tumor resection; however, there were still cases of recurrence, and unresected patients were at risk of progression to systemic amyloidosis. The efficacy of radiotherapy and chemotherapy was currently uncertain. Conclusion Early clinical and pathological diagnosis is crucial, and surgical intervention is the primary treatment option for this disease. Although patients usually have a favorable prognosis, long-term monitoring is necessary to detect potential relapses and initiate timely intervention.

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The Promising Role of Selenium and Yeast in the Fight Against Protein Amyloidosis

Kieliszek,

Sapazhenkava

2024

Biol Trace Elem Res

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In recent years, increasing attention has been paid to research on diseases related to the deposition of misfolded proteins (amyloids) in various organs. Moreover, modern scientists emphasise the importance of selenium as a bioelement necessary for the proper functioning of living organisms. The inorganic form of selenium—sodium selenite (redox-active)—can prevent the formation of an insoluble polymer in proteins. It is very important to undertake tasks aimed at understanding the mechanisms of action of this element in inhibiting the formation of various types of amyloid. Furthermore, yeast cells play an important role in this matter as a eukaryotic model organism, which is intensively used in molecular research on protein amyloidosis. Due to the lack of appropriate treatment in the general population, the problem of amyloidosis remains unsolved. This extracellular accumulation of amyloid is one of the main factors responsible for the occurrence of Alzheimer’s disease. The review presented here contains scientific information discussing a brief description of the possibility of amyloid formation in cells and the use of selenium as a factor preventing the formation of these protein aggregates. Recent studies have shown that the yeast model can be successfully used as a eukaryotic organism in biotechnological research aimed at understanding the essence of the entire amyloidosis process. Understanding the mechanisms that regulate the reaction of yeast to selenium and the phenomenon of amyloidosis is important in the aetiology and pathogenesis of various disease states. Therefore, it is imperative to conduct further research and analysis aimed at explaining and confirming the role of selenium in the processes of protein misfolding disorders. The rest of the article discusses the characteristics of food protein amyloidosis and their use in the food industry. During such tests, their toxicity is checked because not all food proteins can produce amyloid that is toxic to cells. It should also be noted that a moderate diet is beneficial for the corresponding disease relief caused by amyloidosis.

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The spectrum of pulmonary amyloidosis

Cited by 9 publications

References 113 publications

Tracheobronchial Amyloidosis Accompanied with Asthma: A Case Report and a Mini-Review

Tracheobronchial Amyloidosis Accompanied with Asthma: A Case Report and a Mini-Review

Nasopharyngeal amyloidoma: report of three cases and review of the literature

The Promising Role of Selenium and Yeast in the Fight Against Protein Amyloidosis

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