The spectrum of renal abnormalities in patients with psoriasis

Abstract

The presence of abnormal urinalysis was not more common in patients with psoriasis than in controls. However, the increased prevalence of pathologic albuminuria and its positive correlation with psoriasis severity may suggest subclinical glomerular dysfunction in these patients.

PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy

“…Although psoriasis is a common chronic inflammatory disorder of the skin, increasing evidence has demonstrated that psoriasis is associated with an increased risk of CKD and urinary albumin excretion [26, 27]. A population-based cohort study demonstrated that moderate to severe psoriasis was associated with an increased risk of CKD, independent of traditional risk factors [10].…”

“…In another cross sectional study, Yang et al reported that renal failure was more prevalent in patients with severe psoriasis than in age- and sex-matched controls [28]. In addition, multiple cross-sectional studies had also observed a greater prevalence of microalbuminuria [26]. Psoriatic nephropathy is recently described.…”

“…Nephropathy associated with psoriasis has been increasingly reported in recent years. These kidney diseases include IgA nephropathy [29, 30], MN [11–14], membranoproliferative glomerulonephritis [31], focal segmental glomerulosclerosis [32], minimal change disease [33], AA-amyloidosis [34], and therapy-related tubular-interstitial alteration [26]. …”

Renal Infarction in a Patient with Psoriasis: Case Report

“…15,16 Bu nedenle, psöriyazisli hastalarda hem arteryel hem de venöz tromboembolik olaylar açısından dikkatli olunmalıdır. 12 Sol böğür ağrısı şikâyeti ile başvuran erişkin psöriyazisli bu olgumuzda, hematüri ve yüksek serum LDH düzeyi saptanmasıyla renal infarktüsten şüphelenilmiş, arteryel tromboza neden olabilecek çevresel ve genetik etkenler, aile anamnezi ve eşlik eden venöz tromboemboli varlığı araştırılmış, sigara kullanma ve psöriyazis hastalığı dışında ek bir predispozan faktör tespit edilememiştir.…”

Psoriasis and the Life Cycle of Persistent Life Effects

“…131,132 In a population-based cohort study, psoriasis was an independent risk factor for moderate to advanced chronic kidney disease among patients with severe psoriasis, but not for individuals with mild psoriasis. 131 Furthermore, the age specific adjusted hazard ratio for individuals with chronic kidney disease was 3.82 (95% CI, 3.15-4.64) for patients aged 30 and 2.00 (95%CI, 1.86-2.17) for patients aged 60, demonstrating the greater risk among the younger age group compared with individuals without psoriasis in similar age groups, suggesting that individuals with psoriasis may be affected with chronic kidney disease at a younger age than those without psoriasis.…”