We prove the Schrödinger operator with infinitely many point interactions in R d (d = 1, 2, 3) is self-adjoint if the support of the interactions is decomposed into uniformly discrete clusters. Using this fact, we prove the self-adjointness of the Schrödinger operator with point interactions on a random perturbation of a lattice or on the Poisson configuration. We also determine the spectrum of the Schrödinger operators with random point interactions of Poisson-Anderson type.