The spectrum of Vogt-Koyanagi-Harada disease in South India

Murthy, Somasheila I; Moreker, Mayur R; Sangwan, Veena; Khanna, Rohit C; Tejwani, Sushma

doi:10.1007/s10792-007-9046-9

Cited by 28 publications

(13 citation statements)

References 11 publications

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“…In Brazil, 70% of VKH patients were female, 45 in the USA, 78.7%, 46 and in India, 84.4%. 47 VKH tends to affect patients with Asian, Middle Eastern, Hispanic and Native American ancestry. 48, 49 Acute VKH uveitis frequently presents with bilateral multifocal exudative retinal detachments.…”

Section: Female Predominant Uveitides With Systemic Involvementmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

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Uveitides can be due to non-infectious and infectious etiologies. It has been observed that there is a gender difference with a greater preponderance of non-infectious uveitis in women than in men. This review will describe both non-infectious and infectious uveitides and describes some of the current autoimmune mechanisms thought to be underlying the gender difference. It will specifically look at non-infectious uveitides with systemic involvement including juvenile idiopathic arthritis, spondyloarthopathies, sarcoidosis, Behçet’s disease, and Vogt-Koyanagi-Harada disease and at uveitides without systemic involvement including sympathetic ophthalmia, birdshot chorioretinitis, and the white dot syndromes. Infectious uveitides like acute retinal necrosis, progressive outer retinal necrosis, and cytomegalovirus mediated uveitis will be mentioned. Different uveitides with female- or male- predominance are presented and discussed.

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Section: Female Predominant Uveitides With Systemic Involvementmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

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“…However, conflicting results were found in Indian patients. In general, the mean age of VKH patients in India at disease onset is 37 years, 29 whereas the three VKH patients presenting as AACG in India was 31.7 years. 15 It is not yet known why there is a difference concerning the age at disease onset among Chinese, Japanese and Indian VKH patients with an increased IOP.…”

Section: Discussionmentioning

confidence: 96%

Vogt-Koyanagi-Harada disease presenting as acute angle closure glaucoma at onset

Yang

Liu

Zhou

et al. 2011

Clinical &Amp; Experimental Ophthalmology

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“…By reviewing 75 VKH patients seen at the National Eye Institute between 1978 and 1996, 78.7% of patients were females [7]. In other areas, the recently reported proportions of affected females with VKH are 78.9% in Mexico [9]; 62.9–75% in Saudi Arabia [8, 30, 31]; 65.3% in Tunisia, North Africa [32]; 73.7% in Japan [33]; 84.44% in South India [34]; 70% in Brazil [35]; and 71.1% in Turkey [36]. Sukavatcharin et al reported that females constituted 62.5% of patients in 48 case series in a Hispanic population [37].…”

Section: Gender and Vkhmentioning

confidence: 99%

Gender Differences in Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia

Wang

Chan

2014

Journal of Ophthalmology

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Vogt-Koyanagi-Harada disease (VKH) and sympathetic ophthalmia (SO) are types of T-cell mediated autoimmune granulomatous uveitis. Although the two diseases share common clinical features, they have certain differences in gender predilections. VKH classically has been reported as more prevalent in females than males, yet some studies in Japan and China have not found differences in gender prevalence. Male patients have a higher risk of chorioretinal degeneration, vitiligo, and worse prognosis. Conversely, the changing levels of estrogen/progesterone during pregnancy and the menstrual cycle as well as higher levels of TGF-β show a protective role in females. Potential causes of female predilection for VKH are associated with HLA-DR and HLA-DQ alleles. SO, a bilateral granulomatous uveitis, occurs in the context of one eye after a penetrating injury due to trauma or surgery. In contrast to the female dominance in VKH, males are more frequently affected by SO due to a higher incidence of ocular injury, especially during wartime. However, no gender predilection of SO has been reported in postsurgical cases. No clinically different manifestations are revealed between males and females in SO secondary to either ocular trauma or surgery. The potential causes of the gender difference may provide hints on future treatment and disease evaluation.

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The spectrum of Vogt-Koyanagi-Harada disease in South India

Abstract: Majority of patients with ocular VKH presented with anterior uveitis and serous retinal detachments and disc edema. Extra-ocular signs are rare in our patients. Visual prognosis is good with treatment with adequate long-term corticosteroids and immunosuppressive agents.

Cited by 28 publications

References 11 publications

The Role of Sex in Uveitis and Ocular Inflammation

The Role of Sex in Uveitis and Ocular Inflammation

Vogt-Koyanagi-Harada disease presenting as acute angle closure glaucoma at onset

Gender Differences in Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia

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