The speed of reinfusion affects the vascular system during ozone major autohemotherapy

Abstract

Ozone major autohemotherapy (O-MAHT) is a way of ozonetherapy administration consisting of drawing patient's venous blood, mixing with oxygen/ozone, and reinfusing it into the vein. Some ozone therapists reported side effects during the O-MAHT, but the origin has not been described yet. We investigated the effect of blood drawing velocity during O-MAHT to see its effects on the vascular system and symptomatology. We administered O-MAHT to 11 subjects, and we interleaved fast and slow reinfusions. We monitored cerebral macrocirculation with transcranial Doppler (TCD) and tissue microcirculation with near-infrared spectroscopy (NIRS). Annoying symptoms appeared just during the fast reinfusion periods. NIRS and TCD parameters revealed vasoconstriction during fast reinfusion and improved metabolism during slow reinfusion. Overall, our investigation well discriminated fast from slow reinfusion velocity.

Comments on the optimal use of medical ozone in clinics versus the Ozone High Dose Therapy (OHT) approach

“…Considering that the mean blood pressure is about 127 mmHg (range 115–140 mmHg), i.e. 0.16 atm, and that the normal blood infusion speed is close to 15 drops/min, at 0.9 atm the number of blood drops might be approximately next to 84 drops/min, so falling within the fast reinfusion reported by our studies [ 1 , 25 ]. Moreover, we seriously wondered if adding oxygen to the reinfusion process at positive pressure does not cause embolism.…”

“…Our group recently investigated the effect of the speed in the reinfusion of the ozonated blood in an O 2 -O 3 -MAHT, by using a near-infrared spectra (NIRS) analysis of the blood flow [ 25 ]. During fast reinfusion (80 drops/min) a decrease in oxygenated hemoglobin (O 2 Hb) was observed, whereas during slow reinfusion (50 drops/min) an increase in the vascular bed of microcirculation, with increase in O 2 Hb was reported [ 25 ]. Considering that the mean blood pressure is about 127 mmHg (range 115–140 mmHg), i.e.…”

The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial

“…Potential toxicity, difficulty attaining adequate concentrations at the infection site, and compliance complications should be considered, as well (7-9); therefore, search for complementary treatments seems vital. vantages, ozone therapy has been the focus of many researchers (10)(11)(12)(13)(14)(15)(16). Ozone seems to have the most significant oxidation effects among oxidants and is known for destroying proteins in microorganism membranes (17).…”

Ozone therapy in veterinary medicine: clinical indications and techniques

“…The Major ozonated autohemotherapy (MAH) consists of collecting a sample blood volume in a bag containing anticoagulant, then mixing it with O 2 -O 3 and administering intravenously. Variations in microcirculation and metabolic changes that have been stable over time have been observed, such as an increase in cerebral oxygenation after about 1.5 hours of ozonated blood infusion and an increase in cytochrome c oxidase activity and concentration for up to 40 min after the end of treatment (BALLARDINI, 2006;RIMINI et al, 2016;TSUZUKI et al, 2015).…”