The Spermatogenic Ig Superfamily/Synaptic Cell Adhesion Molecule Mast-Cell Adhesion Molecule Promotes Interaction with Nerves

Furuno, Tadahide; Ito, Akihiko; Koma, Yoshiaki; Watabe, Kenji; Yokozaki, Hiroshi; Bienenstock, John; Nakanishi, Mamoru; Kitamura, Yukihiko

doi:10.4049/jimmunol.174.11.6934

Cited by 106 publications

(120 citation statements)

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“…The Cadms (cell adhesion molecules) are a family of type I transmembrane proteins that have been described in several pathological and physiological processes such as the progression of lung and other cancers (reviewed in Murakami, 2005), mast cell adhesion (Ito et al, 2003(Ito et al, , 2007bFuruno et al, 2005;Ito and Oonuma, 2006), spermatogenesis (Wakayama et al, 2001;Wakayama et al, 2003;Fujita et al, 2006;van der Weyden et al, 2006;Yamada et al, 2006), epithelium development and homeostasis (Ito et al, 2007b), and central nervous system development (Biederer et al, 2002;Sara et al, 2005;Spiegel et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish

Pietri

Easley-Neal

Wilson

et al. 2007

Developmental Dynamics

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The Cadm (cell adhesion molecule) family of cell adhesion molecules (also known as IGSF4, SynCAM, Necl and TSLC) has been implicated in a multitude of physiological and pathological processes, such as spermatogenesis, synapse formation and lung cancer. The precise mechanisms by which these adhesion molecules mediate these diverse functions remain unknown. To investigate mechanisms of action of these molecules during development, we have identified zebrafish orthologs of Cadm family members and have examined their expression patterns during development and in the adult. Zebrafish possess six cadm genes. Sequence comparisons and phylogenetic analysis suggest that four of the zebrafish cadm genes represent duplicates of two tetrapod Cadm genes, whereas the other two cadm genes are single orthologs of tetrapod Cadm genes. All six zebrafish cadms are expressed throughout the nervous system both during development and in the adult. The spatial and temporal patterns of expression suggest multiple roles for Cadms during nervous system development. Developmental Dynamics 237:233-246, 2008.

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Section: Introductionmentioning

confidence: 99%

“…This interaction grants Cadm1 the ability to modulate the immune system by enhancing mast cell response to nerve activation (Ito et al, 2003;Furuno et al, 2005;Ito and Oonuma, 2006;Ito et al, 2007a). Another function of Cadm1 in the immune system includes immunosurveillance.…”

Section: Introductionmentioning

confidence: 99%

Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish

Pietri

Easley-Neal

Wilson

et al. 2007

Developmental Dynamics

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“…The adhesion between the neurites and mast cells was considered to be formed by specific bonds between CADM1 molecules (24,(26)(27)(28), which exist on the cell membrane of both neurites and mast cells. In addition, because the nonspecific adhesion due to electrostatic interaction would not be negligible, the contribution of the nonspecific bonds was also evaluated as F break M-S .…”

Section: Maturation Process Between the Neurites And Mast Cellsmentioning

confidence: 99%

“…In such tissues, they tend to exist near or in contact with neurites of nerve cells (20); electron microscopic observation has revealed that the intercellular distance is generally <20 nm (21,22). Many mast cells adhere to neurites when neurogenic inflammation occurs (23), and Furuno et al reported that mast cells and nerve cells bidirectionally transduce signal molecules in an adhesion-dependent manner (24,25). From these reports, the coculture system is generally regarded as a reproductive model of the anatomical and functional relationship between them.…”

Section: Introductionmentioning

confidence: 99%

“…From these reports, the coculture system is generally regarded as a reproductive model of the anatomical and functional relationship between them. The adhesion is considered to be formed by specific bonds between cell adhesion molecules known as cell adhesion molecule-1s (CADM1s) (24,(26)(27)(28), which are membranespanning glycoproteins belonging to the immunoglobulin (Ig) superfamily (29)(30)(31)(32) and function by forming a dimer on the cell membrane (33)(34)(35).…”

Section: Introductionmentioning

confidence: 99%

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Time-Course Statistical Evaluation of Intercellular Adhesion Maturation by Femtosecond Laser Impulse

Iino

Hagiyama

Furuno

et al. 2016

Biophysical Journal

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The maturation of intercellular adhesion is an essential process for establishing the signal transduction network in living cells. Although the maturation is naturally considered to enhance the signal transduction, the relationship between the signal transduction and the maturation process has not been revealed in detail using time-course data. Here, using a coculture of mast cells and neurites, differences in maturation between individual cells were estimated as a function of the adhesion strength by our original single-cell measurement method utilizing a laser-induced impulsive force. When an intense femtosecond laser is focused into a culture medium under a microscope, shock and stress waves are generated at the laser focal point that exert an impulsive force on individual cells. In our method, this impulse is used to break the adhesion between a mast cell and a neurite. The magnitude of the impulse is then quantified by a local force-measurement system utilizing an atomic force microscope, and the adhesion strength is estimated from the threshold of the impulse required to break the adhesion. The measurement is conducted within 1 min/cell, and thus, data on the individual differences of the adhesion strength can be obtained within only a few hours. Coculturing of neurites and mast cells for 4 h resulted in a specific adhesion that was stronger than the nonspecific adhesions between the substrate and mast cells. In the time-course investigation, we identified two distinct temporal patterns of adhesion: 1) the strength at 24 h was the same as the initial strength; and 2) the strength increased threefold from baseline and became saturated within 24 h. Based on these results, the distribution of CADM1 adhesion molecules in the neurites was suggested to be inhomogeneous, and the relationship between adhesion maturation and the signal-transduction process was considered.

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Mast Cells

Oboki¹,

Hagiyama²,

Inoué³

et al. 2013

Encyclopedia of Life Sciences

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Mast cell is a type of connective tissue cell but originates from the haematopoietic stem cell. Adult mouse mast cell‐committed progenitor, which is the common myeloid progenitor lineage, can be identified in bone marrow. Additionally, a unique progenitor having bipotent activity (e.g. basophil/mast cell progenitor) is found in the spleen, which is unique lymphoid organ having a function to sustain hematopoiesis. Mast cell‐lineage specification is coordinated by transcription factor GATA‐binding protein‐1 (GATA‐1), GATA‐2, PU.1 and CCAAT/enhancer‐binding protein‐α, and its maturation process is regulated by microphthalmia transcription factor. Mast cell progenitors distribute in various tissues through the blood stream by using known/unknown chemokines and integrins and located around blood vessels, peripheral nerves or lymphatic vessels. The most established function of mast cells is amplification of immunoglobulin E‐dependent hypersensitivity reaction. Mouse models have mainly been utilised to understand the mast cell biology and have given us many evidences especially in the developmental origin of mast cell. Although controversial results have emerged in the role of mast cells, recent advances in next generation mast cell‐deficient mice models will improve the knowledge about the roles of mast cell in various disease settings. Key Concepts: Adult mouse mast cell progenitors (MCPs), which differentiate through the stage of common myeloid progenitor, are able to detect by combination of specific cell surface markers. Adult mouse MCPs are identifiable in bone marrow. Bipotent basophil/mast cell progenitors (BMCPs) can be found in the spleen. The developmental and functional relationship of these cells remains to be determined. Mouse mast cells are classified into two types (mucosal and connective tissue type) by histological sites (e.g. mucosa or connective tissue). However, human mast cells are classified into two types by its protease expression pattern (e.g. tryptase + chymase − type and tryptase + chymase + type). Recently, nonclassical protease expression patterns have been found in human and mouse mast cells. Mast cell heterogeneity is determined by tissue microenvironments. Although KIT mutant mice have long been used for the study of mast cell function, some subsidiary effects are concerned because KIT mutant mice have several defects other than mast cells. Recently developed genetically engineered mast cell deficient mice may give us more convincing evidences of mast cell function in various diseases except for the established function of IgE‐mast cell in immediate hypersensitivity.

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The Spermatogenic Ig Superfamily/Synaptic Cell Adhesion Molecule Mast-Cell Adhesion Molecule Promotes Interaction with Nerves

Cited by 106 publications

References 50 publications

Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish

Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish

Time-Course Statistical Evaluation of Intercellular Adhesion Maturation by Femtosecond Laser Impulse

Mast Cells

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