The sphingosine 1‐phosphate receptor agonist FTY720 interfered the distribution of dendritic cell and induced the maternal‐fetal immune tolerance

Abstract

We hypothesized that FTY720 may reduce the number of DCs that were chemoattracted to the maternal-fetal interface by downregulating the expression of CCR7, which ultimately induces maternal-fetal immune tolerance.

Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

“…Although the phase I trial generated promising results for psoriasis, no reports are currently available with regard to its use in AD. Besides the major impact on the segregation of T cells, the biological activity of S1P and its receptors on innate immunity 172 , epidermal keratinocytes [173][174][175][176] and on DCs [177][178][179] remain interesting elements to be considered in explaining the mode of action of this class of compounds in AD.…”

Vagal‐α7nAChR signaling attenuates allergic asthma responses and facilitates asthma tolerance by regulating inflammatory group 2 innate lymphoid cells

“…Almost all iILC2s are reportedly positive for the proliferation marker Ki67, which indicates they exhibit a high proliferative potential 20 . More recent data also suggest that S1P‐dependent inter‐organ trafficking of iILC2s from the gut to the lung contributes to type 2 inflammation in antihelminth defense; however, the S1P inhibitor FTY720 42 did not affect IL‐25‐induced intestinal ILC2 proliferation and only blocked iILC2 tissue accumulation 21 . Our study attempts to close the gap in knowledge surrounding the role of iILC2s in asthma and their neuroimmune regulatory mechanisms.…”

“…Future studies will probe deeply into the role of α7nAChR in regulating iILC2s and S1P‐dependent gut–lung circulation in OT. FTY720, which antagonizes the S1P signaling pathway, 21,38,39,42–44 will also be useful in future neuroimmune research to investigate the role of various vagal components (such as PCF, NMU and α7nAChR) in regulating S1P‐dependent trafficking of different immune cells. The coordination between different components in vagal circuits is also important, and the interaction between different neural pathways is worth exploring as well.…”

SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

“…94 In addition, S1P inhibits maturation and differentiation of DCs by increasing IL-10 with subsequent suppression of Th1 immune response and prompting Th2. 95 These changes lead to inhibition release of proinflammatory cytokines from DCs with activation release of anti-inflammatory cytokines. HDL is also regarded as a treatment of chronic inflammatory diseases by suppressing T cells function and proliferation with modulation expression of Th1/Th17.…”

“…In addition, S1P inhibits maturation and differentiation of DCs by increasing IL‐10 with subsequent suppression of Th1 immune response and prompting Th2 95 . These changes lead to inhibition release of pro‐inflammatory cytokines from DCs with activation release of anti‐inflammatory cytokines.…”