The spike effect of acute respiratory syndrome coronavirus 2 and coronavirus disease 2019 vaccines on blood pressure

Angeli, Fabio; Zappa, Martina; Reboldi, Gianpaolo; Gentile, Giorgio; Trapasso, Monica; Spanevello, Antonio; Verdecchia, Paolo

doi:10.1016/j.ejim.2022.12.004

Cited by 16 publications

(10 citation statements)

References 107 publications

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“…The exact mechanism linking SARS-CoV-2 infection and COVID-19 vaccines and acute elevations in BP is still debated but could involve the failure of the counter-regulatory renin-angiotensin-system (RAS) axis [26] . It is well known that the binding of the Spike (S) protein to angiotensin converting enzyme 2 (ACE2) receptors on the cell surface mediates the virus entry into cells, thereby promoting ACE2 internalization and degradation, and loss of ACE2 activities.…”

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confidence: 99%

“…Contrary to ACE2, POP/PRCP levels were found to be significantly positively correlated with age and the presence of several metabolic and cardiovascular disorders [30] . Therefore, some authors have suggested that the adverse effects of COVID-19 vaccines mediated by the interaction of S protein with ACE2 may be particularly pronounced in younger patients with a better cardiovascular risk profile [26] . Regarding hypertension, this hypothesis is supported by some, but not all the above studies.…”

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confidence: 99%

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The relationship between COVID-19 vaccines and increased blood pressure: A word of caution

Buso

Rosei

Muiesan

2023

European Journal of Internal Medicine

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confidence: 99%

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confidence: 99%

The relationship between COVID-19 vaccines and increased blood pressure: A word of caution

Buso

Rosei

Muiesan

2023

European Journal of Internal Medicine

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“…Hence, one reasonable hypothesis is that reduced expression of DDIAS could potentially facilitate SARS-CoV-2 infection through the downregulation of pathways involved in DNA repairment and inflammation. Another prioritized gene from this region was PRCP , an angiotensinase that has been linked to hypertension and for which a hypothesis on its role on COVID-19 progression has been raised 24,25 .…”

Section: Discussionmentioning

confidence: 99%

Novel risk loci for COVID-19 hospitalization among admixed American populations

Carracedo

2023

Preprint

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The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.

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“…Some authors suggested that the potential link may involve the dysfunction of the counter-regulatory renin-angiotensin system axis. Moreover, studies have indicated that the increase in blood pressure after COVID-19 vaccination, mediated by the interaction between the spike protein and the angiotensin-converting enzyme 2, may be more frequent in younger subjects [43]. However, it is important to note that not all studies support this explanation, due to variability in age ranges [44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Evolution of Cardiovascular Risk Factors in Post-COVID Patients

Abdulan,

Feller,

Oancea

et al. 2023

JCM

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(1) Background: SARS-CoV-2 infection has been a subject of extensive discussion in the medical field, particularly in relation to the risk factors and effective treatment strategies for reducing the negative health outcomes associated with the virus. However, researchers indicate that individuals in the recovery phase after COVID-19 experience a range of symptoms that significantly impact their overall well-being and quality of life. At present, there is insufficient evidence to substantiate the claim that patients in the post-acute phase of COVID-19 are at an elevated risk of developing new-onset hypertension or even metabolic syndrome. The current study aimed to assess the risk of cardiovascular diseases after COVID-19 and the optimal treatment of these conditions. (2) Methods: This research was conducted at the Cardiovascular Rehabilitation Clinic of the Iasi Clinical Rehabilitation Hospital (Romania) between the 1st of September and 31st of December 2022. From a total of 551 patients hospitalized in that period, 70 patients with multiple comorbidities were selected. This study included patients over 18 years old who were diagnosed with COVID-19 within the past 30 days. (3) Results: The included patients were mostly women (62.9%) from the urban area (61.4%). Comparing the post-COVID-19 period to the pre-COVID-19 one, it was observed that the risk of hypertension increased from 69.57% to 90% among the subjects (p = 0.005). Risk factors for the new onset of hypertension were identified as age, female gender, and an elevated body mass index. Moreover, the number of patients with dyslipidemia doubled, and a higher body mass index was noted. (4) Conclusions: Our findings suggest that patients affected by COVID-19 are at an increased risk of developing hypertension and related disorders.

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The spike effect of acute respiratory syndrome coronavirus 2 and coronavirus disease 2019 vaccines on blood pressure

Cited by 16 publications

References 107 publications

The relationship between COVID-19 vaccines and increased blood pressure: A word of caution

The relationship between COVID-19 vaccines and increased blood pressure: A word of caution

Novel risk loci for COVID-19 hospitalization among admixed American populations

Evolution of Cardiovascular Risk Factors in Post-COVID Patients

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