The Stability of an Oral Liquid Formulation of Cysteamine

Brodrick, Alison; Broughton, Helen M.; Oakley, Rosemary

doi:10.1111/j.1365-2710.1981.tb00889.x

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…The degradation of cys is a zero-order reaction, indicating that the concentration of cys decreases linearly with time [ 35 ]. The removal of oxygen from a solution of cys by packing under nitrogen and the presence of ascorbic acid (antioxidant) increase the stability of the molecule, but show a lower efficacy in comparison with chelating agents such as disodium edetate [ 36 ].…”

Section: Physicochemical Properties and Stability Of Cysmentioning

confidence: 99%

Challenges for cysteamine stabilization, quantification, and biological effects improvement

Atallah

Charcosset

Greige‐Gerges

2020

Journal of Pharmaceutical Analysis

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Section: Physicochemical Properties and Stability Of Cysmentioning

confidence: 99%

Challenges for cysteamine stabilization, quantification, and biological effects improvement

Atallah

Charcosset

Greige‐Gerges

2020

Journal of Pharmaceutical Analysis

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“…In our study, the Cysteamine drug was divided into small portions under nitrogen to avoid oxidation during dispensing the drug. Fresh solutions were prepared to have maximized effect, as cysteamine stability in high pH and normal atmospheric conditions is difficult due to quick oxidation reaction (7)(8)(9) . Complete eradication of bacterial biofilm was obtained at 200 mg/mL of Cysteamine.…”

Section: Discussionmentioning

confidence: 99%

“…(6) Cysteamine drug (Cysteamine 98%Rt, Fluka, Switzerland) was divided into small portions under nitrogen conditions using a nitrogen chamber to avoid oxidation during dispensing the drug. Fresh solutions were prepared to have maximized effect (7)(8)(9) . The powders of tested medications were measured and dispensed using sensitive balance.…”

Section: Sample Preparationmentioning

confidence: 99%

The Antibacterial Effect of Cysteamine and Its Combinations With Various Intracanal Medications Against Enterococcus Faecalis

Elgammal

mahraan

ashry

et al. 2022

Egyptian Dental Journal

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Background:The microbiological ecosystem is considered the main obstacle in endodontics. Therefore, canal disinfection became a great priority. Aim of the study:This study was established to assess cysteamine's antibacterial effect against E. Faecalis and compare the improvement effect to its combination with various intracanal medicaments. Methods and Materials:Cleaning and shaping were performed on human single-rooted teeth then inoculated by E. faecalis biofilm. Samples were divided randomly into three groups: Group I to verify the maturation of E. faecalis biofilm inside the root canal using SEM. Group II were divided into four subgroups according to the intracanal medication used. Subgroup A was treated with Cysteamine. Subgroup B was treated with Chlorhexidine Cysteamine combination. Subgroup C was treated with Calcium hydroxide (CaOH) Cysteamine combination. Subgroup D was treated with Triple antibiotic paste Cysteamine combination. Group III were divided into two subgroups treated with plain gel: positive control and negative control. Samples collected from root canals were used for viable count (CFU/ml). Log transformation of the data was carried out. The statistical significance level was set at P < 0.05. Results:There was a significant difference between different groups (p<0.001). Post hoc pairwise comparisons showed statistically significant difference between subgroups except for the CaOH Cysteamine combination subgroup and TAP Cysteamine combination subgroup. Conclusion:Cysteamine usage provides a synergistic antibacterial effect with other intracanal medications. CHX Cysteamine combination was the most effective antibacterial drug that provided effectiveness against E. faecalis.

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“…The removal of oxygen from a solution of cysteamine by packing under nitrogen, and the addition of ascorbic acid, increase its stability. However, this technique showed lower efficacy in comparison with chelating agents such as disodium edetate [61,62]. In addition, it is also important to take into account the nature of the container, being preferable to use those materials that prevent the passage of oxygen inside.…”

Section: Cysteamine Structure and Stability Propertiesmentioning

confidence: 99%

Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives

et al. 2020

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Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in different tissues and organs. Although renal damage prevails during initial stages, the deposition of cystine crystals in the cornea causes severe ocular manifestations. At present, cysteamine is the only topical effective treatment for ocular cystinosis. The lack of investment by the pharmaceutical industry, together with the limited stability of cysteamine, make it available only as two marketed presentations (Cystaran® and Cystadrops®) and as compounding formulations prepared in pharmacy departments. Even so, new drug delivery systems (DDSs) need to be developed, allowing more comfortable dosage schedules that favor patient adherence. In the last decades, different research groups have focused on the development of hydrogels, nanowafers and contact lenses, allowing a sustained cysteamine release. In parallel, different determination methods and strategies to increase the stability of the formulations have also been developed. This comprehensive review aims to compile all the challenges and advances related to new cysteamine DDSs, analytical determination methods, and possible future therapeutic alternatives for treating cystinosis.

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The Stability of an Oral Liquid Formulation of Cysteamine

Abstract: SUMMARY A formula for cysteamine syrup is presented together with stability data obtained after analysis by high performance liquid chromatography.

Cited by 8 publications

References 3 publications

Challenges for cysteamine stabilization, quantification, and biological effects improvement

Challenges for cysteamine stabilization, quantification, and biological effects improvement

The Antibacterial Effect of Cysteamine and Its Combinations With Various Intracanal Medications Against Enterococcus Faecalis

Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives

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