The Stability of Metabolic Syndrome in Children and Adolescents

Abstract

Cutoff-point-based definitions for pediatric metabolic syndrome have substantial instability in the short and long term. The value of making a cutoff-point-based diagnosis of metabolic syndrome during childhood or adolescence remains in question.

A Diagnosis of the Metabolic Syndrome in Youth That Resolves by Adult Life Is Associated With a Normalization of High Carotid Intima-Media Thickness and Type 2 Diabetes Mellitus Risk

“…These data are consistent with findings from other studies that demonstrate the relative short-and longer-term instability in the diagnosis of youth MetS (3,6,7). Several factors might contribute to this.…”

“…A recent consensus statement (2) has called for more research, particularly in longitudinal studies from youth to adulthood, on a number of areas relating to pediatric MetS before a definition for the clinical diagnosis of MetS among youth is considered. Some of the unwillingness to issue a definite definition is due to concerns over the demonstrated short-term instability of a categorical diagnosis of MetS in the pediatric setting (6,7). Further to this, however, is that-irrespective of instability-the ability to predict future disease status is critically important.…”

Obesity and the metabolic syndrome in pediatric psoriasis

“…A consensus definition and criteria for the diagnosis of the metabolic syndrome in adults has been established; (41) the diagnosis of the metabolic syndrome in adolescents, with a significant number of adolescents failing to meet diagnostic criteria upon long-term follow-up. (44,45) Long-term follow-up of a cohort of children ages 6 to 19 years of age from the Cincinnati clinic of the National Heart, Lung, and Blood Institute LRC Prevalence Study demonstrated an association between a diagnosis of the metabolic syndrome during childhood, as defined by a BMI ≥ the age-specific 90 th percentile and the following criteria:…”

Metabolic syndrome in children

“…Porém, é importante reconhecer que um enfoque na síndrome metabólica, em vez de nos fatores de risco individuais, pode destoar da abordagem mais eficaz de cuidados preventivos ou tratamento. Primeiro, a síndro-me metabólica não se mantém ao longo da infância 6,7 , da infância para o início da vida adulta 8 e particularmente em crianças nas categorias de risco maior 9 . Por consequência, importantes órgãos consultivos levantaram dúvidas sobre sua utilidade em crianças 10 .…”