The Stability of Penicillinase-producing Strains of Staphylococcus aureus

Fairbrother, R.W.; Parker, Laura; Eaton, Brian

doi:10.1099/00221287-10-2-309

Cited by 34 publications

(23 citation statements)

References 6 publications

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“…This finding is supported by Bondi et al (1958) whose report stated that growth of S. aureus at 45°C increased the rate of loss of penicillinase production. The present finding is also consistent with the report that growth at elevated temperature (44°C) increased the rate of loss of penicillinase resistance in some strains of Staphylococci (Fairbrother et al, 1954). May et al (1964) showed that loss at both penicillin and tetracycline resistance during growth of a strain of S. aureus occurred at 43°C to 44°C.…”

supporting

confidence: 82%

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Elevated temperature induced resistance markers reduction of some selected clinical bacterial pathogens

Otajevwo¹,

Otasowie²

2017

J. Microbiol. Antimicrob.

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Axenic cultures of Klebsiella pneumoniae, Escherichia coli and-7 S. aureus broth dilution recorded 87.0±4.3% RR. There was more than 50% RR in 10 -5 and 10 -6 S. aureus broth dilutions at 40°C and more than 50% RR in all three dilutions at 45°C. Vertically, the three pathogens in 10 -7 broth dilution and at 40°C recorded a common RR of 58.1±11.2% against gentamicin. Broth culture dilutions of 10 -5 and 10 -6 of all pathogens produced RR of 74.6±22.2 and 74.6±21.0%, respectively against ofloxacin with no significant RR against the other drugs at the temperatures tested. The implications of these findings are discussed.

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supporting

confidence: 82%

“…Fairbrother et al (1954) reported that growth of some strains of Staphylococci at elevated temperature (44°C) increased the rate of loss of penicillin resistance. May et al (1964) reported loss of both penicillin and tetracycline resistance by S. aureus when grown at elevated temperature of 43 to 44°C.…”

Section: Introductionmentioning

confidence: 99%

Elevated temperature induced resistance markers reduction of some selected clinical bacterial pathogens

Otajevwo¹,

Otasowie²

2017

J. Microbiol. Antimicrob.

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“…They include plasmids conferring resistance to antibiotics (Fairbrother, Parker & Eaton, 1954;Novick, 1963;Chabbert, Baudens & Gerbaud, 1964;May et al 1964;Dornbusch, Hallander & Lofquist, 1969;Novick, 1969), heavy metal ions (Richmond & John, I 964; Novick I 967), toxin and pigment production (Serwin-Massieu, I 961 ; Dornbusch, Hallander & Lofquist, 1969). Some strains carry more than one plasmid and strains carrying two different penicillinase plasmids have been constructed artificially (Richmond,I 968) as have strains carrying both chromosomal and extrachromosomal genes for penicillinase production (Asheshov,I 969).…”

Section: Introductionmentioning

confidence: 99%

Transduction of Penicillinase Production and Methicillin Resistance-Enterotoxin B Production in Strains of Staphylococcus aureus

Dornbusch¹,

Hallander²

1973

Journal of General Microbiology

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It is suggested that wild strain ~~4 9 1 6 of Staphylococcus aureus harbours at least two plasmids. One of them is responsible for penicillinase production and resistance to metallic ions and the other for methicillin and cephalothin resistance together with enterotoxin B production. These properties were eliminated en bloc with acridines as well as separately at different rates. Transductions were performed to restore the eliminated characters with typing phages 29 and 88. Recombination of the markers for penicillinase production and methicillin resistance on the transduced fragment seems advantageous for selection of methicillin resistance.

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“…Thus, it is currently accepted that the increase in the prevalence of penicillinase-producing strains is primarily the result of selection by penicillin, though phage-mediated transduction of penicillinase-producing capacity R. P. NOVICK may be a contributory factor (Ritz & Baldwin, 1961). On the other hand, it has been observed that penicillinase-positive strains give rise frequently to penicillinase-negative variants (Barber, 1949; Bondi, Kornblum & de Saint Phalle, 1953;Fairbrother, Parker & Eaton,!1954). These strains are usually stable in that, like wildtype penicillinase-negatives, they do not revert to penicillinase production (Fairbrother, 1956).…”

Section: Introductionmentioning

confidence: 99%

Analysis by Transduction of Mutations affecting Penicillinase Formation in Staphylococcus aureus

Novick

1963

Journal of General Microbiology

399

223

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SUMMARYSeventy-five mutants with alterations in penicillinase formation were isolated from a strain of Staphylococcus aureus inducible for penicillinase. The mutants fell into three main categories on the basis of penicillinase activity and inducibility : (i) microinducible mutants which formed decreased amounts of penicillinase but retained the property of inducibility ; (ii) penicillinase-negative variants which produced no detectable penicillinase and which showed no effect of inoculum size on penicillin resistance; (iii) strains with a wide range of penicillinase activities that produced the enzyme constitutively. Treatment of the wild-type strain with ethylmethane sulphonate increased the frequency of occurrence of microinducible and constitutive mutants but did not alter the incidence of the penicillinase-negative variants which were present in all cultures at a frequency of about Representative mutants of each class were examined for ability to revert to wild type and to give wild-type recombinants in transductional crosses. The constitutive strains and the microinducible strains behaved like point mutants in that they reverted and in that they gave wild-type recombinants. The penicillinase-negative mutants, however, behaved differently in that they were not observed to revert nor did they give wild-type recombinants in crosses, either with one another or with microinducible or constitutive mutants. A naturally occurring penicillinase-negative strain of S . aureus behaved similarly to the penicillinase-negative mutants in these respects. The possibility that the penicillinase region in s. aureus is associated with a plasmid and thus inherited extrachromosomally is considered and discussed. The properties of the penicillinase-negative variants could be explained as resulting from the loss of such a plasmid. Consistent with the plasmid hypothesis is the finding that ultraviolet irradiation of transducing phage produced an exponential decline of transducing titre for penicillinase ; against it is the failure of acridine orange to increase the frequency of the penicillinasenegative variants.

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The Stability of Penicillinase-producing Strains of Staphylococcus aureus

Cited by 34 publications

References 6 publications

Elevated temperature induced resistance markers reduction of some selected clinical bacterial pathogens

Elevated temperature induced resistance markers reduction of some selected clinical bacterial pathogens

Transduction of Penicillinase Production and Methicillin Resistance-Enterotoxin B Production in Strains of Staphylococcus aureus

Analysis by Transduction of Mutations affecting Penicillinase Formation in Staphylococcus aureus

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