The Stability of Sodium Nitroprusside Infusion During Administration by Motorized Syringe-Pump

Abstract

This study examined the stability of concentrated sodium nitroprusside infusions during administration by a motorized syringe‐pump system. Sodium nitroprusside and the free‐cyanide degradation product were determined in infusion samples collected over periods of up to 24 h. Measures which were taken to protect the delivery system from light, ensured satisfactory stability of the infusion for at least 12 h from the time of preparation.

The availability of diltiazem: A study on the sorption by intravenous delivery systems and on the stability of the drug

“…Other investigators have demonstrated degradation of drugs in solution, for instance while exposed to normal daylight. This appears to be the case for drugs such as nifedipine, nimodipine, nitroprusside (Sewell et al 1985;Jakobsen & Mikkelsen 1986; Al-Turk et a1 1988). Regardless of the cause, the overall decrease in availability may range from 10 to 90% of the initial drug concentration.…”