The staged synthesis of 2-methylimidazole from ethylenediamine and acetic acid in the presence of a bifunctional aluminoplatinum catalyst

Gitis, K. M.; Raevskaya, N. I.; Isagulyants, G. V.

doi:10.1007/bf00863570

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2011

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“…For example, a process involving acetaldehyde, glyoxal and ammonium carbonate furnishes the desired compound in an excellent 95% yield ( Scheme 37 ). Also, a condensation reaction between ethylenediamine and acetic acid catalysed by γ-Al 2 O 3 at high temperatures gives 2-methylimidazole ( 187 ) in approximately 90% yield [ 56 ].…”

Section: Reviewmentioning

confidence: 99%

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

Baumann¹,

Baxendale²,

Ley³

et al. 2011

Beilstein J. Org. Chem.

503

269

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SummaryThis review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent literature. Owing to the vast number of potential structures, we have concentrated only on those drugs containing five-membered heterocycles and focused principally on the assembly of the heterocyclic core. In order to target the most representative chemical entities the examples discussed have been selected from the top 200 best selling drugs of recent years.

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Section: Reviewmentioning

confidence: 99%