The standardized uptake value for F‐18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival

Abstract

Batch cultures of Lactococcus lactis NCDO 2118 and IL 1403 were performed in a Couette bioreactor operated in the modulated wavy vortex flow and the turbulent regimes. This study provides an overall analysis taking into account both mechanical stress and mixing in a Couette bioreactor. A unique phenotypic aspect has been proved to occur only in the modulated wavy vortex flow regime for the two studied strains, namely that the cells become entrapped in a filamentous form. No change in the metabolic behavior of the cells has been observed. The polymeric matrix has been microscopically observed through FISH and fluorescent lectin binding, showing cells entrapped in a glycoconjugate matrix. All hypotheses regarding insufficient mixing as a cause of this phenotype have been discarded, leading to the conclusion that this particular phenotypic feature is essentially due a combined effect of mechanical stress and flow structure. Particle size measurement during the fermentation course indicates that formation of filamentous form results from a continuous aggregation started in the early stages of the cultivation. According to our results a minimum shear is required to induce the ability for cells to aggregate. Then, it appears that both flow structure and mechanical stress (shear) are responsible for the appearance of such a filamentous form. As far as the authors know, this is the first experimental evidence of a bio polymerization induced by the flow structure. Biotechnol. Bioeng. 2011; 108:559–571. © 2010 Wiley Periodicals, Inc.

Pelvic lymph node F‐18 fluorodeoxyglucose uptake as a prognostic biomarker in newly diagnosed patients with locally advanced cervical cancer

“…Previous research has demonstrated that a high primary cervical SUV max is predictive of an increased risk of pelvic lymph node involvement, 11 but the results of the current study indicate that the SUV PLN is an independent prognostic factor. Using regression analysis, the SUV PLN was not found to be strongly correlated with the SUV cervix .…”

“…11 Similarly, we also found in a separate study that patients demonstrating highly heterogeneous FDG uptake within the cervical tumor had increased risks of lymph node metastasis at diagnosis, persistent disease after treatment, and pelvic disease recurrence, and worse progression-free survival; the heterogeneity of FDG uptake was found to be independent of the SUV max . 12 Taken together, these studies suggest FDG-PET findings have significant value for the prognosis of patients with cervical cancer.…”

“…8,11,12 The results of the current study suggest that the SUV max of the pelvic lymph nodes represents a new FDG-PET-based prognostic biomarker.…”

Pilot study of combined FDG‐PET and dynamic contrast‐enhanced CT of locally advanced cervical carcinoma before and during concurrent chemoradiotherapy suggests association between changes in tumor blood volume and treatment response

“…This is likely the reason we did not observe previously reported associations between FDG‐PET imaging biomarkers and clinical outcomes 10, 28, 29. Additionally, all patients showed good local control, so we were not able to assess imaging parameters that correlate with local failure.…”

18F‐fluoro‐2‐deoxy‐D‐glucose–positron emission tomography (PET)/PET‐computed tomography in carcinoma of the cervix

“…Their report is published in this issue of Cancer. 24 The authors demonstrated that the SUV max at the primary tumor site was an independent predictive biomarker of lymph node status, persistent disease after treatment, pelvic recurrence, and overall survival outcome in patients with cervical cancer. However, the primary tumor SUV max was not related to patient-specific factors, such as histology, tumor stage, or tumor volume.…”