The Stapes in Otosclerosis: Osteoarthritis of an Ear Ossicle

Clarke-Brodber, Anna-Lee; Taxy, Jerome B.

doi:10.1007/s12105-020-01269-2

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…These diseases include but are not limited to, Alport syndrome, otosclerosis and ankylosis of the stapes FP, Meniere's disease with endolymphatic hydrops. 40,41 Patients with endolymphatic hydrops could be predisposed to SNHL from FP fenestration due to proximity of the saccular membrane to the stapes FP. 42 A variety of mechanisms for the delivery of therapeutics to the inner ear have been proposed.…”

Section: Discussionmentioning

confidence: 99%

“…Pre‐existing otologic diseases may be exceptions to the proposed anatomic minimums. These diseases include but are not limited to, Alport syndrome, otosclerosis and ankylosis of the stapes FP, Meniere's disease with endolymphatic hydrops 40,41 . Patients with endolymphatic hydrops could be predisposed to SNHL from FP fenestration due to proximity of the saccular membrane to the stapes FP 42 …”

Section: Discussionmentioning

confidence: 99%

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Surgical Considerations in Inner Ear Gene Therapy from Human Temporal Bone Anatomy

Brown,

Zhu,

Rohani

et al. 2024

The Laryngoscope

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Objective(s)Recently directed methods of inner ear drug delivery underscore the necessity for understanding critical anatomical dimensions. This study examines anatomical measurements of the human middle and inner ear relevant for inner ear drug delivery studied with three different imaging modalities.MethodsPost‐mortem human temporal bones were analyzed using human temporal bone histopathology (N = 24), micro computerized tomography (μCT; N = 4), and synchrotron radiation phase‐contrast imaging (SR‐PCI; N = 7). Nine measurements involving the oval and round windows were performed when relevant anatomical structures were visualized for subsequent age‐controlled analysis, and comparisons were made between imaging methods.ResultsCombined human temporal bone histopathology showed the mean distance to the saccule from the center of the stapes footplate (FP) was 2.07 ± 0.357 mm and the minimum distance was 1.23 mm. The mean distance from the round window membrane (RWM) to the osseous spiral lamina (OSL) was 1.75 ± 0.199 mm and the minimum distance was 1.43 mm. Instruments inserted up to 1 mm past the center of the FP are unlikely to cause saccular damage, provided there are no endolymphatic hydrops. Similarly, instruments inserted up to 1 mm through the RWM in the trajectory toward the OSL are unlikely to cause OSL damage.ConclusionThe combined analyses of inner‐ear dimensions of age‐controlled groups and imaging modalities demonstrate critical dimensions of importance to consider when inserting delivery vehicles into the human cochlea.Level of EvidenceN/A Laryngoscope, 2024

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical Considerations in Inner Ear Gene Therapy from Human Temporal Bone Anatomy

Brown,

Zhu,

Rohani

et al. 2024

The Laryngoscope

View full text Add to dashboard Cite

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“…Otosclerosis is considered as one of the most One of the most common causes of hearing loss is otosclerosis. 10 Slowing the course of hearing loss is a common goal for early detected cases with fast progression. 11 However, otosclerosis has no known medical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…12 Different surgical approaches are available as management of otosclerosis like total and partial stapedectomy, as well as stapedotomy. 10 Different variations of stapedotomy are present and even all were tried in the past, however the main principle of this approach is to establish a calibrated hole inside the footplate. 13 The new technique, Piezosurgery depends on a device producing specific ultrasound waves at a frequency (22 000-35 000 Hz) and the generated ultrasonic vibrations are used for cutting and modulation the shape of bones.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study between Piezosurgery and Conventional Surgical Method in the Treatment of Otosclerosis

Ramez Sabry Fahim,

Mohamed Sherif Ahmed Abd Elmonem,

Ashraf Mahmoud Khaled

et al. 2023

ijocs

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Aim: This work aimed to compare Piezosurgery stapedotomy with the conventional approach in the management of otosclerosis in terms of intraoperative time, postoperative complications, and air-bone gap improvement.Methods: This randomized controlled clinical trial was conducted in Beni-Suef University hospital from August 2021 to June 2022 according to the ethical considerations of the local institutional review board. It included 40 patients suffering from hearing loss due to otosclerosis, diagnosed based on clinical features, audiometry and impedancemetry. Patients were randomly divided into two groups: group P underwent stapedotomy by the Piezosurgery medical device, and group C underwent stapedotomy by the conventional method.Results: Both groups were matched regarding their baseline characteristics. The air bone gap (ABG) postoperatively reached a mean of 7.7±6.7 dB (median=6) in group P and 7.6±6.8 (median=7) dB in group C, with no significant difference. The percentage of reduction of A-B gap was 76.21%±17.6% in group P (Piezosurgery), while group C (conventional) was 75.8% ±18.7%, with no significant difference. The operative time in group P was (35.5± 4.5) minutes vs (29.7 ±3.2) minutes in group C, with a significant difference. Regarding the complication, there was no significant difference between Piezosurgery and conventional surgery regarding intraoperative and postoperative complications (P-value > 0.05). Conclusion:This work concluded no difference between conventional techniques and Piezosurgery in (ABG) reduction postoperatively, intraoperative, and postoperative complications, only surgical time was longer in Piezosurgery group and was statistically significant.

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“…The most common changes were fissures in the articular surface of the stapes head (65%), cartilage erosion (49%), and surface irregularities. Osteophytes have been observed sporadically [ 13 ]. These observations are in line with our research.…”

Section: Discussionmentioning

confidence: 99%

Impact of Otosclerosis on Auditory Ossicle Remodeling: A Scanning Electron Microscopy Analysis of Stapes Head Overloads

Wiatr

2023

Med Sci Monit

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Background Otosclerosis is a pathology that interferes with the conduction of vibrations to the inner ear, triggering changes in the auditory ossicles and their associated joints due to mechanical overload. This study primarily aims to evaluate these overload-induced modifications in the stapes head resulting from the immobilization of the base of the third auditory ossicle in otosclerosis patients. Material/Methods We conducted a comparative analysis of patients undergoing their first surgery for otosclerosis. The test group consisted of 31 patients who underwent stapedotomy between 2020–2021. For comparison, we utilized a control group comprising stapes samples extracted during vestibular schwannoma surgeries via a transcochlear approach. A prospective analysis of bone tissue surface topography and chemical composition was executed using scanning electron microscopy (SEM). Results SEM analysis of the stapes head in otosclerosis patients relative to the control group displayed no significant differences in chemical composition or the presence of otosclerotic foci. Nonetheless, various forms of bone tissue surface damage were noted on the stapes head in all otosclerosis patients. Mild changes were evident in 90% of the samples, while small linear bone tissue fractures were observed in 58% of the samples. Furthermore, minor osteophytic changes were detected in 16% of the samples. Conclusions The immobilization of the stapes base by otosclerotic foci instigates overloads in the incus-stapes joint, leading to the eventual remodeling of the stapes head articular surface.

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The Stapes in Otosclerosis: Osteoarthritis of an Ear Ossicle

Cited by 5 publications

References 8 publications

Surgical Considerations in Inner Ear Gene Therapy from Human Temporal Bone Anatomy

Surgical Considerations in Inner Ear Gene Therapy from Human Temporal Bone Anatomy

Comparative Study between Piezosurgery and Conventional Surgical Method in the Treatment of Otosclerosis

Impact of Otosclerosis on Auditory Ossicle Remodeling: A Scanning Electron Microscopy Analysis of Stapes Head Overloads

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