The state of “freeze-for-all” in human ARTs

Basile, Natalia; Garcia-Velasco, Juan A.

doi:10.1007/s10815-016-0799-9

Cited by 27 publications

(20 citation statements)

References 83 publications

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“…Fresh embryo transfer (ET) is still the standard procedure for in-vitro fertilization (IVF) treatments, although recent scientific data have shown the potential benefit of performing cycle segmentation with deferred ET, known as the freeze-all policy [2][3][4][5][6] . It is unknown whether this strategy can be used for all patients, irrespective of their ovarian response and hormone levels during controlled ovarian stimulation (COS) [7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Roque

Valle

Sampaio

et al. 2018

Ultrasound in Obstet & Gyne

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The freeze-all strategy, compared with fresh ET, had no impact on IVF outcomes in POR patients as defined according to the Bologna criteria. Multicenter studies including large numbers of patients should be carried out to confirm the results of this study and reach conclusions about the potential benefits of the freeze-all policy for poor responders. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

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Section: Introductionmentioning

confidence: 99%

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Roque

Valle

Sampaio

et al. 2018

Ultrasound in Obstet & Gyne

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“…For couple who take IVF, the procedure has been previously described (21). All the oocytes will be inseminated with 2-5×10 6 The procedure of ICSI has been previously described (22). After injection, oocytes are transferred to the standard culture dishes in conventional incubators.…”

Section: Interventionsmentioning

confidence: 99%

“…In recent years, with the development of vitrification, the survival rates of thawed embryos was greatly improved as compared with slow-freezing (5). There are some medical indications for elective frozen embryo transfer (eFET) or 'freeze-all' approach, including hydrosalpinx, increased risk of ovarian hyperstimulation syndrome (OHSS), elevated progesterone levels, genetic screening, low responders, inadequate uterine cavity, high blood pressure and Zika virus (6). Women undergo progestin-primed ovarian stimulation (PPOS) protocol or luteal phase stimulation protocol also require eFET.…”

Section: Introductionmentioning

confidence: 99%

Fresh versus frozen single embryo transfer in Chinese women of advanced age undergoing IVF/ICSI: a study protocol for a randomized controlled trial

Chen¹,

Huang²,

Liu³

et al. 2020

Preprint

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Background: Elective frozen cleavage embryo transfer resulted in significantly higher live birth rate in patients with polycystic ovary syndrome but not in ovulatory women compared with fresh embryo transfer. Further, elective single frozen blastocyst transfer had significantly higher live birth rate in ovulatory women compared with single fresh blastocyst transfer. However, it is unknown whether single frozen cleavage embryo transfer results in higher cumulative live birth rate in women of advanced age undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). The aim of this study is to compare the effectiveness of frozen cleavage embryo transfer with fresh cleavage embryo transfer in Chinese women of advanced age. Methods: This study is a double-blind randomized controlled clinical trial (1:1 treatment ratio of frozen embryo transfer vs. fresh embryo transfer). A total of 840 women of advanced age with normal ovarian reserve undergoing the first cycle of IVF or ICSI will be enrolled and randomized into two parallel groups. Participants in group A will undergo frozen single cleavage embryo transfer, and participants in group B will undergo fresh single cleavage embryo transfer. The primary outcome is the cumulative live birth rate of the trial IVF/ICSI cycle within 12 months after randomization. This study is powered to detect an absolute difference of 8% (23% vs 15%) at the significance level of 0.05 and 80% statistical power based on a two-sided test. Discussion: The results of this study will provide evidence for the efficacy and safety of frozen cleavage embryo transfer compared with fresh cleavage embryo transfer in women of advanced age undergoing IVF/ICSI. Trial registration: Chinese Clinical Trial Registry, ChiCTR2000029330. Registered on 25 Jan 2020. Keywords: Frozen embryo transfer, advanced age, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), live birth, randomized controlled trial.

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“…Since then, embryo cryopreservation has become a widely used technic in assisted reproductive technology (ART), allowing the preservation of the remaining embryos following a fresh transfer for future pregnancies and as a modern tool to reduce multiple births by encouraging patients to transfer a single embryo [1,68]. Additional indications for embryo cryopreservation are the embryo banking for preimplantation genetic screening, elective deferred embryo transfer, when the patient is at risk of a hyperstimulation and for fertility preservation [66,69]. Thus, embryo cryopreservation greatly increased the safety and efficacy of IVF treatments and enable the later use of all the embryos obtained from a single oocyte pick-up.…”

Section: Current Status Of Embryo Cryopreservationmentioning

confidence: 99%

Clinical Outcomes of Assisted Reproductive Techniques Using Cryopreserved Gametes and Embryos in Human Medicine

Waterstone¹,

Anastácio²,

Rodriguez‐Wallberg³

2018

Cryopreservation Biotechnology in Biomedical and Biological Sciences

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The methods of cryopreservation play a key role in assisted reproductive technique (ART) treatments, as they increase the efficacy of the treatments by allowing banking of supernumerary embryos for later use. It has been recently proposed that these methods could also increase the safety of ART treatments, by reducing complications such as ovarian hyperstimulation during early pregnancy; thus, the policy of total freeze for later differed transfer of embryos has been proposed. Also of great importance, cryopreservation of oocytes and spermatozoa has permitted gamete storage for long term facilitating practical routines such as the gamete banking for third-party reproductive treatment. In this chapter, the clinical indications and treatment outcomes will be revised and data updated on the safety of using cryopreservation methods in ART treatments.

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The state of “freeze-for-all” in human ARTs

Cited by 27 publications

References 83 publications

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Fresh versus frozen single embryo transfer in Chinese women of advanced age undergoing IVF/ICSI: a study protocol for a randomized controlled trial

Clinical Outcomes of Assisted Reproductive Techniques Using Cryopreserved Gametes and Embryos in Human Medicine

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