The state of processes of lipid peroxidation and hemostasis in plague intoxication

Чеснокова, Н. П.; Afanasieva, G.; Понукалина, Е. В.

doi:10.1016/s0928-4680(98)80340-4

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2011

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“…Activation of proteolytic systems, e.g. fi brinolytic system, is typical of endotoxemia [10,12]. No enhanced FG utilization typical of the initial state of DIC-syndrome was observed 2-4 h after LPS administration.…”

Section: Resultsmentioning

confidence: 99%

Pathogenetic Role of Yersinia pseudotuberculosis Endotoxin in Hemostasis and Microcirculation Disturbances

Кузнецова

Сомова²,

Плехова³

et al. 2011

Bull Exp Biol Med

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We studied the role of Y. pseudotuberculosis endotoxin (LPS) in the pathogenesis of hemostasis and microcirculation disorders. It was found that changes in the hemostasis system after injection of LPS had biphasic character corresponding to the stages of DIC syndrome development. Pathomorphological findings in animals with endotoxemia induced by Y. pseudotuberculosis LPS attested to increased permeability and destruction of the vascular endothelium in the microcirculatory bed and focal degenerative and necrotic changes in cells of the target organs (kidney, liver, and lungs) progressing with increasing the duration of the pathological process, which was determined by microcirculation disturbances and development of multiple organ failure.

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Section: Resultsmentioning

confidence: 99%