The state of stroke services across the globe: Report of World Stroke Organization–World Health Organization surveys

Owolabi, Mayowa; Thrift, Amanda G.; Martins, Sheila; Johnson, Walter D.; Pandian, Jeyaraj Durai; Abd‐Allah, Foad; Varghese, Cherian; Mahal, Ajay; Yaria, Joseph; Phan, Hoang; Roth, Gregory A.; Gall, Seana; Beare, Richard; Phan, Thanh G.; Mikulík, Robert; Norrving, Bo; Feigin, Valery

doi:10.1177/17474930211019568

Cited by 104 publications

(78 citation statements)

References 29 publications

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“…Stroke is becoming a heavy burden all over the world, especially in China, 1 which occurs at a high rate, resulting in neurological dysfunction. 2 Stroke was divided into two types, hemorrhagic and ischemic strokes.…”

Section: Introductionmentioning

confidence: 99%

LncRNA FTX Regulates Angiogenesis Through miR-342-3p/SPI1 Axis in Stroke

Gao¹,

Wang²

2021

NDT

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Background Long non-coding RNAs (lnc-RNAs) and microRNAs (miRNAs) play key roles in the development of stroke. However, the role of lncRNA FTX in stroke is limited known. Methods Real-time polymerase chain reaction (real-time PCR) assays were used to measure the expression of lncRNA FTX, miR-342-3p and SPI1. Western blot assays were employed to examine SPI1 protein expression. The cell viability was measured by CCk8 assay. Cell migration was detected by wound healing assays and transwell assays. Angiogenesis was evaluated by matrigel tube formation assays. The interaction between lncRNA FTX, miR-342-3p and SPI1 was confirmed by site-directed mutagenesis and luciferase assays. Results The expression of lncRNA FTX was down-regulated in blood sample from stroke patients, MAO mice tissues and OGD/R treated BMECs. Overexpression of lncRNA FTX could increase the cell viability, migration and angiogenesis in OGD/R treated BMECs. LncRNA FTX could act as a ceRNA for miR-342-3p. Furthermore, miR-342-3p inhibition increased migration and angiogenesis in OGD/R-induced BMECs. Dual-luciferase reporter assay verified that SPI1 was a target of miR-342-3p. Conclusion In summary, lncRNA FTX enhanced the angiogenesis in stroke by acting as a sponge of miR-342-3p to regulate the expression of SPI1 level.

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Section: Introductionmentioning

confidence: 99%

LncRNA FTX Regulates Angiogenesis Through miR-342-3p/SPI1 Axis in Stroke

Gao¹,

Wang²

2021

NDT

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“…Unfortunately, despite of the increment from 17% in 2018 to 42% in 2020, it was restricted to a few hospitals and poorly distributed in several countries. A similar situation occurs around the world with higher availability of telemedicine in high-income countries, where the population already has access to better organized stroke care and specialists (27).…”

Section: Discussionmentioning

confidence: 77%

“…The service might even be available, but the patients only get access months after stroke onset, missing out the most important period for stroke recovery. The situation is similar in other LMIC countries (27). The training of healthcare professionals remains limited, especially in primary care, which is the critical step in the detection and monitoring of cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 84%

“…Stroke units are a highly effective strategy in acute care and early rehabilitation to reduce stroke morbidity and mortality (26) and their implementation should be a priority in Latin America. Unfortunately, they are underutilized or unused, as shown in a recent paper that evaluate stroke services across the world (27), with the worst situation in LMIC.…”

Section: Discussionmentioning

confidence: 99%

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Fighting Against Stroke in Latin America: A Joint Effort of Medical Professional Societies and Governments

et al. 2021

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Introduction: Stroke is one of the leading causes of death in Latin America, a region with countless gaps to be addressed to decrease its burden. In 2018, at the first Latin American Stroke Ministerial Meeting, stroke physician and healthcare manager representatives from 13 countries signed the Declaration of Gramado with the priorities to improve the region, with the commitment to implement all evidence-based strategies for stroke care. The second meeting in March 2020 reviewed the achievements in 2 years and discussed new objectives. This paper will review the 2-year advances and future plans of the Latin American alliance for stroke.Method: In March 2020, a survey based on the Declaration of Gramado items was sent to the neurologists participants of the Stroke Ministerial Meetings. The results were confirmed with representatives of the Ministries of Health and leaders from the countries at the second Latin American Stroke Ministerial Meeting.Results: In 2 years, public stroke awareness initiatives increased from 25 to 75% of countries. All countries have started programs to encourage physical activity, and there has been an increase in the number of countries that implement, at least partially, strategies to identify and treat hypertension, diabetes, and lifestyle risk factors. Programs to identify and treat dyslipidemia and atrial fibrillation still remained poor. The number of stroke centers increased from 322 to 448, all of them providing intravenous thrombolysis, with an increase in countries with stroke units. All countries have mechanical thrombectomy, but mostly restricted to a few private hospitals. Pre-hospital organization remains limited. The utilization of telemedicine has increased but is restricted to a few hospitals and is not widely available throughout the country. Patients have late, if any, access to rehabilitation after hospital discharge.Conclusion: The initiative to collaborate, exchange experiences, and unite societies and governments to improve stroke care in Latin America has yielded good results. Important advances have been made in the region in terms of increasing the number of acute stroke care services, implementing reperfusion treatments and creating programs for the detection and treatment of risk factors. We hope that this approach can reduce inequalities in stroke care in Latin America and serves as a model for other under-resourced environments.

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“…To develop an economic case for the pragmatic solutions for the primary prevention of stroke, we measured the global economic burden of stroke. The estimated economic burden accounted for the global financial costs of providing acute care to patients with stroke in hospital, including rehabilitation, and in the post-acute phase, including medical care, social services, and informal caregiving (appendix pp [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. We also estimated the income losses associated with people who have had a stroke and their households due to premature death and disability, and we estimated production losses as a result of stroke (appendix pp 7-20).…”

Section: The Cost Burden Of Stroke and The Economic Case For Preventionmentioning

confidence: 99%

Primary stroke prevention worldwide: translating evidence into action

Owolabi

Thrift

Mahal

et al. 2022

The Lancet Public Health

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282

127

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Summary Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, including task-shifting and sharing and health system re-engineering. Implementation of primary stroke prevention involves patients, health professionals, funders, policy makers, implementation partners, and the entire population along the life course.

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The state of stroke services across the globe: Report of World Stroke Organization–World Health Organization surveys

Cited by 104 publications

References 29 publications

LncRNA FTX Regulates Angiogenesis Through miR-342-3p/SPI1 Axis in Stroke

LncRNA FTX Regulates Angiogenesis Through miR-342-3p/SPI1 Axis in Stroke

Fighting Against Stroke in Latin America: A Joint Effort of Medical Professional Societies and Governments

Primary stroke prevention worldwide: translating evidence into action

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