With continuous growth in the complexity, scale, and dynamics of space systems, information integration (II) becomes an essential strategy for managing system complexity and tackling dynamic changes and uncertainties in space missions [1], [2], [3]. Space II (SII) is in high demaind so as to meet the system requirements of latency, heterogeneity, communication, networking, security, and resilience. The study of SII has attracted much attention from scientists and engineers across all engineering domains. We proposed this special section (SS) to solicit, identify, and disseminate new contributions to the theories, methodologies, tools, and case studies of SII that are developed to address some unique challenges of space systems such as security, safety, reliability, and resilience and help T-AES readers gain a basic understanding of the cutting-edge space technologies and the directions of future advancement of SII. The editorial team has received 33 high-quality submissions from around the world, and a total of 21 manuscripts were ultimately accepted through a rigorous peer-reviewing process.