The state of the art in acute pancreatitis research

Abstract

This paper comprehensively analyzes the treatment methods for acute pancreatitis. By delving into the advantages and disadvantages of various current treatment strategies in terms of efficacy, safety, and feasibility, it aims to provide a useful reference for clinical treatment. Furthermore, the paper also focuses on the shortcomings and challenges of current treatments, seeking to explore emerging therapeutic methods to improve patient outcomes and quality of life. To achieve this goal, the effectiveness and limitations of existing treatments are summarized, with attention paid to emerging strategies such as exosome therapy and targeted treatments, highlighting their potential as shown in clinical trials and practice. The paper further elaborates on the potential benefits these new treatments may offer to patients with acute pancreatitis, and discusses the current technical challenges and future directions. Ultimately, this paper aims to provide a reference for research and clinical treatment of acute pancreatitis. It hopes to offer useful information to medical professionals, scholars, and patients, aiding in a better understanding of the condition and treatment methods of acute pancreatitis, contributing to the improvement of cure rates and the enhancement of patients' quality of life. The definition and epidemiology of acute pancreatitisAcute pancreatitis (AP) is a serious inflammatory disease that involves acute intense inflammatory response and sudden damage to the pancreas. It is a life-threatening disease, with typical clinical manifestations of upper abdominal or back pain, accompanied by nausea, vomiting and fever. Acute pancreatitis may cause various severe complications, such as pancreatic necrosis, infection, ascites, etc. In recent years, the incidence of acute pancreatitis has increased globally, with about 13 to 45 per 100,000 cases per year [1] . Among them, the incidence rate of males is higher than that of females [2] . Lifestyle factors are one of the main causes of acute pancreatitis. The two most common factors are gallstones and alcohol abuse [3] , and other possible factors include hyperlipidemia, viral infection, trauma, etc.