The State of the Art and Perspective of Structural Study on Skin Stratum Cormeum

Hatta, Ichiro

doi:10.5650/oleoscience.12.25

Cited by 1 publication

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“…In the test cream, the dry coating film had a repeating structure of approximately 10 nm, this was confirmed by small-and wide-angle X-ray scattering and TEM observation ( Figures 2 and 3 ). It has been reported that the intercellular lipids in the human stratum corneum have a short periodic structure of 6 nm and long periodic structure of 13 nm, 24 and display similarities with the structure of the dry coating formed by the heparinoid cream we developed.…”

Section: Discussionmentioning

confidence: 70%

Efficacy of Heparinoid Cream Containing Pseudo-Ceramide for Remission of Atopic Dermatitis

Matsuoka¹,

Okoshi²,

Ito³

et al. 2021

CCID

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Purpose: Atopic dermatitis (AD) is characterized by chronic inflammation, which frequently recurs, is exacerbated, and enters remission. A maintenance remission period is important for AD patients. We developed a formulation for use during AD remission, containing heparinoid and pseudo-ceramide that forms a lamellar structure. We evaluated the allergen permeability and examined the formulation's efficacy in maintaining remission in patients with AD. Materials and Methods: Seventeen AD patients applied a cream containing 0.3% heparinoid and pseudo-ceramide (test cream group, n = 10), or a general cream containing 0.3% heparinoid (control cream group, n = 7) to their arm for four weeks after inducing remission with the application of a steroid cream for two weeks. Results:The lamellar structure of the test cream was confirmed with small-and wide-angle x-ray scattering analysis and observation by transmission electron microscopy. The test cream inhibited the penetration of V8 protease significantly compared to the control cream in vitro. According to AD severity score by dermatologists, the effects remission maintenance of the test cream group were comparable to those of the control cream group. However, the test cream group had a significantly increased skin hydration value compared to the control cream group. A significant decrease in transepidermal water loss, an indicator of skin barrier function, was shown in the test cream group compared to the control cream group. Conclusion:The cream with lamellar structures containing heparinoid and pseudoceramides may inhibit allergen penetration. Moreover, skin properties improved during the remission period; thus, the formulation we developed was suitable for use during the AD remission period.

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Section: Discussionmentioning

confidence: 70%

Efficacy of Heparinoid Cream Containing Pseudo-Ceramide for Remission of Atopic Dermatitis

Matsuoka¹,

Okoshi²,

Ito³

et al. 2021

CCID

View full text Add to dashboard Cite

show abstract

The State of the Art and Perspective of Structural Study on Skin Stratum Cormeum

Abstract: Based upon the wide q-range X-ray scattering study on stratum corneum, I will introduce that not only the structure of the intercellular lipid matrix but also the structure of soft keratin in the corneocytes plays an impor tant role in function of the stratum corneum.

Cited by 1 publication

References 4 publications

Efficacy of Heparinoid Cream Containing Pseudo-Ceramide for Remission of Atopic Dermatitis

Efficacy of Heparinoid Cream Containing Pseudo-Ceramide for Remission of Atopic Dermatitis

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