The state of the vascular wall in adult population of Tomsk in the framework of the project ESSAY RF

Рогоза, А. Н.; Николаевич, Рогоза Анатолий; Кавешников, В. С.; Сергеевич, Кавешников Владимир; Трубачева, И. А.; Анатольевна, Трубачева Ирина; Серебрякова, В. Н.; Николаевна, Серебрякова Виктория; Zairova, A.; Рафхатовна, Заирова Алсу; Zhernakova, Yu V; Валерьевна, Жернакова Юлия; Oshepkova, Ye V; Владимировна, Ощепкова Елена; Карпов, Р. С.; Сергеевич, Карпов Ростислав; Chazova, I Ye; Евгеньевна, Чазова Ирина

doi:10.26442/sg29048

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…CAVI). Данный показатель отражает жесткость аорты и магистральных артерий нижних конечностей, мало зависит от уровня артериально-го давления (АД) в момент измерения, показывает, таким образом, "истинную АЖ" [4]. СЛСИ дает возможность выявить раннее повреждение сосудов, в т.ч.…”

Section: Analysis Of Factors Associated With Arterial Stiffness In Th...unclassified

“…Все обследованные подписывали добровольное информированное согласие на участие в исследовании. Измерение СЛСИ осуществляли аппаратом VaSera-1500 (Fukuda Denshi) в соответствии с методикой, опубликованной ранее [4]. Анализируемая выборка была взвешена по половозрастному составу обследованной популяции, не включала случаи с значениями лодыжечно-плечевого индекса <0,9 (2,5%).…”

Section: материал и методыunclassified

“…Основными детерминантами СЛСИ были -возраст, ИМТ, пол и САД. Ведущая роль возраста в формировании исследуемого показателя не вызывает сомнений [4,5,8,[10][11][12]. Одним из важных, но трудно измеряемых параметров является длительность воздействия ФР.…”

Section: Relationships and Activities: Noneunclassified

“…Полагают, что после возраста АГ является основным фактором, приводящим к росту АЖ. Продемонстрирована умеренная ассоциация САД с СЛСИ в обследованной популяции, что подтверждает данные других исследований [4,5,8,9,11,12]. Ни диастолическое, ни пульсовое АД не отобрались в рассматриваемую модель: по силе взаимосвязи данные показатели уступали САД.…”

Section: Relationships and Activities: Noneunclassified

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Analysis of factors associated with arterial stiffness in the general working-age population

2022

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Aim. To examine associations of cardio-ankle vascular index (CAVI) with classical, behavioral and social risk factors (RFs) of cardiovascular disease (CVD) in adult population.Material and methods. The study included 1365 people (women, 59%) from a representative sample aged 25-64 years (ESSE-RF), who underwent standard cardiology screening and volume sphygmography (VaSera-1500). All respondents signed an informed consent to participate in the study. The analysis included blocks of classical, social and behavioral risk factors for CVD. A linear model was used to identify associations. An error rate of <5% was considered significant.Results. Age, sex, systolic blood pressure (SBP), triglycerides were associated with higher CAVI values, and body mass index (BMI) was associated with lower values, respectively. After 45 years, a direct association with heart rate (HR) became increasingly important, while after 50 years — with diabetes and the intake of beta-blockers, while the association between diabetes and CAVI was observed only among individuals not taking angiotensin-converting enzyme (ACE) inhibitors. A direct association was found with high-sensitivity C-reactive protein (hsCRP) in men, and an inverse association with diuretics in women, respectively. A sedentary work in combination with a history of bronchitis or with positive family history for CVD showed a direct relationship, while a sufficient physical activity (PA) showed an inverse relationship with the studied indicator, but only among people with belowaverage income.Conclusion. According to the data obtained, in addition to age and sex, the following risk factors made a significant contribution to CAVI parameters in the examined population: BMI, SBP, triglycerides, diabetes, HR, intake of betablockers, diuretics, ACE inhibitors; hsCRP, PA. The unfavorable role of betablockers, high HR, diabetes, sedentary work, chronic lung pathology, hereditary burden, as well as the protective role of ACE inhibitors, diuretics and intense PA in relation to arterial stiffness in the working-age population has been shown. Additional studies are needed to determine the nature of a number of associations. The results obtained may contribute to the study of CAVI role in risk stratification and further development of methodological approaches to CVD prevention.

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Section: Analysis Of Factors Associated With Arterial Stiffness In Th...unclassified

Section: материал и методыunclassified

Section: Relationships and Activities: Noneunclassified

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Analysis of factors associated with arterial stiffness in the general working-age population

2022

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Large artery stiffness according to different assessment methods in adult population of St.Petersburg

Alieva

Rotar

Orlov

et al. 2018

Atherosclerosis Supplements

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Model-Based Assessment of the Reference Values of CAVI in Healthy Russian Population and Benchmarking With CAVI0

Safronova,

Kravtsova,

Vavilov

et al. 2023

American Journal of Hypertension

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BACKGROUND Cardio-ankle vascular index (CAVI) and its modified version (CAVI0) are promising non-invasive markers of arterial stiffness, extensively evaluated primarily in the Japanese population. In this work, we performed a model-based analysis of the association between different population characteristics and CAVI or CAVI0 values in healthy Russian subjects and propose a tool for calculating the range of reference values for both types of indices. METHODS The analysis was based on the data from 742 healthy volunteers (mean age 30.4 years; 73.45% men) collected from a multicenter observational study. Basic statistical analysis [analysis of variance, Pearson’s correlation (r), significance tests] and multivariable linear regression were performed in R software (version 4.0.2). Tested covariates included age, sex, BMI, blood pressure, and heart rate (HR). RESULTS No statistically significant difference between healthy men and women were observed for CAVI and CAVI0. In contrast, both indices were positively associated with age (r = 0.49 and r = 0.43, P < 0.001), however, with no clear distinction between subjects of 20–30 and 30–40 years old. Heart rate and blood pressure were also identified as statistically significant predictors following multiple linear regression modeling, but with marginal clinical significance. Finally, the algorithm for the calculation of the expected ranges of CAVI in healthy population was proposed, for a given age category, HR and pulse pressure (PP) values. CONCLUSIONS We have evaluated the quantitative association between various population characteristics, CAVI, and CAVI0 values and established a method for estimating the subject-level reference CAVI and CAVI0 measurements.

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The state of the vascular wall in adult population of Tomsk in the framework of the project ESSAY RF

Cited by 9 publications

References 18 publications

Analysis of factors associated with arterial stiffness in the general working-age population

Analysis of factors associated with arterial stiffness in the general working-age population

Large artery stiffness according to different assessment methods in adult population of St.Petersburg

Model-Based Assessment of the Reference Values of CAVI in Healthy Russian Population and Benchmarking With CAVI0

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