The Status of Glutathione Peroxidase, Superoxide Dismutase, Vitamins A, C, E and Malondialdehyde in Patients with Cardiovascular Disease in Zahedan, Southeast Iran

Karajibani, Mansour; Hashemi, Mohammad; Montazerifar, Farzaneh; Bolouri, Ahmad; Dikshit, Madhurima

doi:10.3177/jnsv.55.309

Cited by 25 publications

(23 citation statements)

References 43 publications

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“…Oxidized LDL is associated with the pathogenesis of atherosclerosis, a key in the early stage of CVD. However, oxidized LDL has a toxic effect on the vascular cells, and the cytotoxic potency of oxidized LDL is related to its content of lipid peroxidation products (20,21). Recent findings show that oxidative stress and lipid peroxidation have a relationship with the pathogenesis of atherosclerosis.…”

Section: Malondialdehyde (Mda)mentioning

confidence: 99%

Study of Oxidants and Antioxidants in Addicts

Karajibani

Montazerifar

Feizabad

2016

Int J High Risk Behav Addict

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Context: This study was a systematic review that aimed to extract published articles regarding oxidant and antioxidants status in opium addiction by searching in PubMed, Google Scholar engine, SID, and Magiran databases. Evidence Acquisition: Sixty-six published articles were investigated in this review, which were selected from studies among the Iranian society and other societies from 1976 to 2015. All articles published in different fields of descriptive-analytical, experimental, and interventional studies were considered. Results: Several studies have shown that with increased production of free radicals and reactive oxygen species (ROS), the enzymatic and non-enzymatic antioxidants such as glutathione (GSH) and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase activities, and also the concentration of vitamins A, E, C and total antioxidant capacity (TAC) decrease in opium addiction. Increased atherogenic indexes such as Low density lipoprotein/high density lipoprotein (LDL/HDL) ratio and malondialdehyde (MDA) may contribute to the increased risk of cardiovascular disease. However, it has also increased other markers of oxidative stress including: isoprostanes, 8-oxoguanine and protein carbonyl. Conclusions: Oxidative stress increases in opium-addicted people. It seems that opium is capable of provoking oxidative stress and also, has harmful effects on lipid profile and antioxidant enzyme. Drug addicts were found to have antioxidant vitamin deficiency.

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Section: Malondialdehyde (Mda)mentioning

confidence: 99%

Study of Oxidants and Antioxidants in Addicts

Karajibani

Montazerifar

Feizabad

2016

Int J High Risk Behav Addict

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“…Serum levels of vitamin E were determined using high pressure liquid chromatography (HPLC) as described previously ( 16 ). Plasma concentration of vitamin C was measured by a spectrophotometric method ( 17 ) as described previously ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

“…SOD and GPx were measured using commercially available kits supplied by Randox Laboratories Ltd (Randox, UK) as described previously ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

Effect of Vitamin E and C Supplements on Antioxidant Defense System in Cardiovascular Disease Patients in Zahedan, Southeast Iran

Karajibani

Hashemi

Montazerifar

et al. 2010

J Nutr Sci Vitaminol

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Summary Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Growing evidence suggest that antioxidant vitamins might reduce the risk of disease outcomes by their ability to scavenge free radicals. The aim of the present study was to evaluate the supplementation of vitamins E and C on oxidant and antioxidant status in CVD patients. We conducted a case-control study with vitamin E (400 IU/d) and vitamin C (500 mg/d) supplementation in 40 CVD patients for 2 mo. Antioxidant (enzymatic and nonenzymatic) and oxidant status were analyzed pre and post supplementation. In the initial stage the activity of both enzymatic and non-enzymatic antioxidants were lower, while the malondialdehyde (MDA) level was elevated ( p Ͻ 0.0001). After intervention, a significant increase in superoxide dismutase (SOD) activity (61.7%), glutathione peroxidase (GPx) activity (59.3%), the levels of vitamin E (83.7%), C (145.3%), total antioxidant capacity (TAC) (62.8%) and a significant decrease in MDA (40%) value were observed ( p Ͻ 0.0001). There was a significant negative correlation between MDA and TAC. The results suggest that supplementation with a combination of vitamins E and C reduced lipid peroxidation and strengthened the antioxidant defense system. Hence, there will be beneficial effects on the heart by reducing oxidative stress in CVD patients.

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“…Previous studies have revealed a significant imbalance of pro-oxidants and antioxidants in patients with CKD and diabetes [15,16,19,24,25]. It is also well known that bilirubin shows an antioxidant capacity, as in neonatal patients with increased bilirubin levels [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates

Üstündağ¹,

Huysal²,

Kahvecioğlu³

et al. 2016

Eur Res J

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Objectives. The total antioxidant capacity (TAC) of a sample can be measured with a ferric reducing antioxidant power (FRAP) assay. There are commercially available kits for FRAP assays, however they are more expensive than in-house kits. We aimed to evaluate a FRAP direct measurement method under our laboratory conditions using a microplate reader and establish reference values to use in future research projects. Methods. An inhouse microplate adaptation of the FRAP method was evaluated. Reference values of FRAP were established for one hundred and twenty subjects aged between 25-55 years. FRAP levels were estimated in 30 serum samples with high glucose concentration, 44 hyperbiluribinemic neonatals and 16 patients receiving renal replacement therapy (RRT). Results. The mean FRAP level was 890±235 µmol/L. The median TAC level was 904 µmol/L. This method was found to be linear up to at least 2000 µmol/L. The intra-and inter-assay coefficients of variation were 2.7-6.7% and 5.3-10.1%, respectively. The mean FRAP level was lower than normal in diabetes and RRT patients and higher in hyperbiluribinemic neonatals (687±209 µmol/L, 609±250 µmol/L and 945±187 µmol/L, respectively). Conclusions. Our reference values give comparable results with the literature. This method is simple, reliable, and inexpensive. It could be used for studies of oxidative stressrelated diseases.Eur Res J 2016;2(2):126-131

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The Status of Glutathione Peroxidase, Superoxide Dismutase, Vitamins A, C, E and Malondialdehyde in Patients with Cardiovascular Disease in Zahedan, Southeast Iran

Cited by 25 publications

References 43 publications

Study of Oxidants and Antioxidants in Addicts

Study of Oxidants and Antioxidants in Addicts

Effect of Vitamin E and C Supplements on Antioxidant Defense System in Cardiovascular Disease Patients in Zahedan, Southeast Iran

Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates

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