The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber

Sturtzel, Baerbel; Dietrich, Annette; Wagner, Karl‐Heinz; Gisinger, Christoph; Elmadfa, Ibrahim

doi:10.1007/s12603-010-0053-6

Cited by 36 publications

(19 citation statements)

References 40 publications

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“…No symptoms and signs are specific for B6 deficiency. In this study, as in other reports, malnutrition, inactivity, old age, low s-albumin and s-ALAT values, and high homocysteine values were associated with B6 deficiency and seem reasonable to have in mind [8,15,17,28,29]. …”

Section: Discussionsupporting

confidence: 87%

Vitamin B6 deficiency and diseases in elderly people – a study in nursing homes

et al. 2013

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BackgroundVitamin deficiency is a cause of health related problems in elderly people. The aims were to study associations between vitamin B6 (B6) and diseases (primarily functional gastrointestinal disorders) in elderly people in nursing homes, the prevalence of B6 deficiency and factors associated with B6 deficiency.MethodsThis cross-sectional study included residents in nursing homes. Demographics, nutritional status (Mini Nutritional Assessment, MNA® ), physical activity, activity of daily living (Katz Index), dietary habits, use of drugs, and psychiatric and somatic diseases were recorded. A blood sample was collected for haematological and biochemical screening, including B6 (p-PLP); p-PLP values < 20 nmol/l indicates B6 deficiency. The results are given as mean (SD).ResultsSixty-one residents (men/women: 22/39) with an age of 85.3 (6.8) years and BMI 25.7 (4.5) kg/m2 were included. Malnutrition and risk of malnutrition were present in 11.5% and 61% respectively. Dietary intake of B6 (mg/day) in men and women were 1.60 (0.30) and 1.18 (0.31) (recommended 1.6 and 1.2 respectively), and 14 (23%) used B6 supplements. Median p-PLP was 20.7 (range <4.0-175.8), 30 subjects (49%) had B6 deficiency. B6 deficiency was associated with old age, low s-alanine aminotransferase and s-albumin, elevated s-homocysteine and inactivity (p-values 0.01-0.03). There were no clinically significant associations between B6 deficiency and somatic or psychiatric disorders, and B6 deficiency was not observed in subjects given B6 supplements.ConclusionsHalf of the residents had vitamin B6 deficiency. Vitamin supplement was effective prophylaxis for deficiency and should be recommended to all elderly people in nursing homes.

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Section: Discussionsupporting

confidence: 87%

Vitamin B6 deficiency and diseases in elderly people – a study in nursing homes

et al. 2013

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“…Commonly this is treated with laxatives but ideally the consumption of whole grains, legumes, fruits and vegetables should be increased (Slavin 2008). Tailored products, such as pea hull fibre added to usual foods (Dahl et al 2003) and oat bran (Sturtzel et al 2010), have been shown to be helpful in improving constipation management, and oat bran was also reported to improve vitamin B12 bioavailability.…”

Section: Physiology Nutrition and Lifestyle Of The Elderlymentioning

confidence: 99%

Ageing of the human metaorganism: the microbial counterpart

Biagi

Candela

Fairweather‐Tait

et al. 2011

AGE

332

206

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Human beings have been recently reviewed as ‘metaorganisms’ as a result of a close symbiotic relationship with the intestinal microbiota. This assumption imposes a more holistic view of the ageing process where dynamics of the interaction between environment, intestinal microbiota and host must be taken into consideration. Age-related physiological changes in the gastrointestinal tract, as well as modification in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbial ecosystem. Here we review the current knowledge of the changes occurring in the gut microbiota of old people, especially in the light of the most recent applications of the modern molecular characterisation techniques. The hypothetical involvement of the age-related gut microbiota unbalances in the inflamm-aging, and immunosenescence processes will also be discussed. Increasing evidence of the importance of the gut microbiota homeostasis for the host health has led to the consideration of medical/nutritional applications of this knowledge through the development of probiotic and prebiotic preparations specific for the aged population. The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed.

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“…Oat bran can reduce serum cholesterol due to it capacity to bind bile acid (Drizikova, Dongowski, Gebhardt, & Habel, 2005). Oat bran may also improve constipation management and B12 bioavailability in the elderly with multiple chronic diseases (Sturtzel, Dietrich, Wagner, Gisinger, & Elmadfa, 2010). Consumption of citrus peel was associated with significant reduction of both serum total and HDL-cholesterol levels (Wisker, Daniel, & Feldheim, 1994).…”

Section: Introductionmentioning

confidence: 99%