The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber

Sturtzel, Baerbel; Dietrich, Annette; Wagner, K. H.; Gisinger, Christoph; Elmadfa, Ibrahim

doi:10.1007/s12603-009-0190-y

Cited by 10 publications

(38 citation statements)

References 39 publications

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“…None of the studies that measured C-reactive protein (7,25,44,77,82,88) , lipoprotein(a) (Lp(a)) (28,79) , fibrinogen (20) or IL-6 (7) found a significant effect of oat consumption on these variables. There is also a lack of evidence for a beneficial effect of oats on endothelial function (70 -72) .…”

Section: Other Outcomesmentioning

confidence: 99%

“…One study (44) reported measuring plasma homocysteine and found that concentrations were reduced by 16 % in response to 12 weeks of oat bran. A Danish study found that plasminogen activator inhibitor-I and factor VII levels decreased significantly by 27 and 7 %, respectively, following a 2-week oat bran v. a low-fibre diet (33) , but no other studies reported measuring these outcomes.…”

Section: Other Outcomesmentioning

confidence: 99%

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Oats and CVD risk markers: a systematic literature review

et al. 2014

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High consumption of whole-grain food such as oats is associated with a reduced risk of CVD and type 2 diabetes. The present study aimed to systematically review the literature describing long-term intervention studies that investigated the effects of oats or oat bran on CVD risk factors. The literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Seventy-six articles describing sixty-nine studies met the inclusion criteria. Most studies lacked statistical power to detect a significant effect of oats on any of the risk factors considered: 59 % of studies had less than thirty subjects in the oat intervention group. Out of sixty-four studies that assessed systemic lipid markers, thirty-seven (58 %) and thirty-four (49 %) showed a significant reduction in total cholesterol (2-19 % reduction) and LDL-cholesterol (4-23 % reduction) respectively, mostly in hypercholesterolaemic subjects. Few studies (three and five, respectively) described significant effects on HDL-cholesterol and TAG concentrations. Only three out of twenty-five studies found a reduction in blood pressure after oat consumption. None of the few studies that measured markers of insulin sensitivity and inflammation found any effect after long-term oat consumption. Long-term dietary intake of oats or oat bran has a beneficial effect on blood cholesterol. However, there is no evidence that it favourably modulates insulin sensitivity. It is still unclear whether increased oat consumption significantly affects other risk markers for CVD risk, and comprehensive, adequately powered and controlled intervention trials are required to address this question.

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Section: Other Outcomesmentioning

confidence: 99%

Section: Other Outcomesmentioning

confidence: 99%

Oats and CVD risk markers: a systematic literature review

et al. 2014

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“…Constipation as a motility disorder is common in the elderly. Lowering plasma levels of homocysteine in nursing home residents improved constipation [16].…”

Section: Introductionmentioning

confidence: 94%

Different pathways involved in the stimulatory effects of homocysteine on rat duodenal smooth muscle

et al. 2017

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Recent studies have confi rmed that hyperhomocysteinemia is associated with gastrointestinal diseases; however, the direct effect of homocysteine on gastrointestinal reactivity still remains unknown. The aim of this study was to demonstrate how homocysteine may affect nitric oxide mediated duodenal relaxation and whether cholinergic receptors and K + channels take part in stimulating motility, as well as to explore whether oxidative stress is associated with homocysteine-mediated effects. Experiments were carried out on male rats, body mass 250-300 g. Two groups of animals were treated by i.p. application of saline and D,L-Hcy (0.6 μmol/g bm). After 2h of incubation, the duodenal segments were prepared for biochemical analysis and contractile response measurements in an organ bath with Tyrode's solution. Effects of TEA (10 mmol/L) and L-NAME (30 μmol/L) on duodenal contractility in the presence of D,L-Hcy (0.6 μmol/g bm) were investigated. Elevated homocysteine levels seem to be of crucial importance for the deterioration of contractility through nitric oxide mediated relaxation, and, in part, by activation of K + channels. Hcy showed direct promuscarinic effects, since 30 min pretreatment of rat duodenum signifi cantly enhanced the contractile effect of increasing concentrations of ACh (10 -9 -10 -2 mol/L). Catalase activity, superoxide dismutase, glutathione peroxidase and the total antioxidant system were reduced while the thiobarbituric acid-reactive substances level was elevated. Our data showed a consistent profi le of gastrointestinal injury elicited by sulfur-containing amino acid-homocysteine. This could contribute to explain, at least in part, the mechanisms involved in human gastrointestinal diseases associated to hyperhomocysteinemia.

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“…It can also help to reduce blood sugar levels, (11) reduce constipation in older people, (12) decrease blood pressure levels, (13) and play a role coronary heart disease reduction (14) .…”

Section: Introductionmentioning

confidence: 99%

Anti-atherosclerotic Effects of Oats (Avena Sativa) on Blood Vessels of Albino Rats’ Tongue

Baker

Moawad

2019

Egyptian Dental Journal

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Atherosclerosis is characterized by vascular areas containing mononuclear and smooth muscle cells proliferation causing the arterial wall to harden and thicken (3) .Atherosclerosis begins with endothelium damage, resulting in dysfunction of the vasodilated ABSTRACT Objective: To investigate anti-atherosclerotic effect of oats against increased fat diet which result in atherosclerosis in albino rats.Methodology: 30 adult male albino rats divided into three groups, 10 rats each: group I: negative control take basal diet, group II take diet with increased cholesterol level for 8 weeks, group III fed on diet with increased cholesterol level for 60 days then given oats-supplemented diet (20% b/w) besides the same diet of cholesterol for another 4 weeks. The animals were euthanized under mild ether anesthesia at the end of 8th week for group II and at the end of 12th week for group III. and the blood was taken from inner canthus of the eye, total serum cholesterol level has been observed and each animal has cholesterol level more than 250 mg/dl was estimated to be hyperlipidemic rat. Rats' tongue carefully dissected out and processed for Haematoxylin & Eosin and alpha smooth muscle actin staining.Results: histological examination revealed that atherosclerosis would lead to endothelial damage of the blood vessels of the tongue; rats received oats in their diet showed regeneration of the endothelial cells. Immuno-histochemical study showed increase positive immunoreactivity in blood vessels of tongue of group II rats that received high fat diet compared with rats of negative control group or rats of oat group Conclusion: including oats in diet can be effective in reducing serum cholesterol.

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The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber

Cited by 10 publications

References 39 publications

Oats and CVD risk markers: a systematic literature review

Oats and CVD risk markers: a systematic literature review

Different pathways involved in the stimulatory effects of homocysteine on rat duodenal smooth muscle

Anti-atherosclerotic Effects of Oats (Avena Sativa) on Blood Vessels of Albino Rats’ Tongue

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