2013
DOI: 10.1155/2013/273498
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The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products

Abstract: An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate), 400 IU vitamin D3, 50 mg magnesium, 7.5 mg zinc, 1 mg copper, 75 μg molybdenum, 250 μg boron per two tablets) were compared to a clinically proven bone formulation (27 mg natural genistein, 400 I… Show more

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Cited by 6 publications
(4 citation statements)
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“…The genistein daily dose was 54 mg and tablets were identical to the placebo in appearance and taste. Genistein serum levels were measured both at baseline and the final visit, as previously described [ 16 , 21 ]. Only the first 11 patients of each group underwent ultrasound studies, due to a budget reduction from the original proposal ( Figure 1 ).…”
Section: Methodsmentioning
confidence: 99%
“…The genistein daily dose was 54 mg and tablets were identical to the placebo in appearance and taste. Genistein serum levels were measured both at baseline and the final visit, as previously described [ 16 , 21 ]. Only the first 11 patients of each group underwent ultrasound studies, due to a budget reduction from the original proposal ( Figure 1 ).…”
Section: Methodsmentioning
confidence: 99%
“…However, these data deserve further investigation to better define the outcome on these pathways in longer time treatment experiments or using different experimental approaches. Nonetheless it is worth to note that genistein has a very intriguing safety profile with nearly dose‐linear pharmacokinetic characteristics , and without hormonal and metabolic effects in paediatric male population . Thus, this work represents a step forward in identifying new promising therapeutic targets in DMD, however it has to be reminded that caution is needed as several therapeutic approaches failed when translated to humans.…”
Section: Discussionmentioning
confidence: 99%
“…Genistein, which mostly exists in a bound state in the natural world, can be rapidly and completely hydrolyzed after entering the human body and reaches its maximum blood drug concentration in less than 2 h . Bitto et al reported that the maximum plasma concentration ( C max ) of genistein reached 1.19 μg/g following the oral administration of 30 mg in adults with an average half-life ( t 1/2 ) of 6.2 h . In Japanese individuals with lower intake of soy isoflavones, the highest plasma concentration of genistein reached 0.89 μg/g following the oral administration of 54 mg with a t 1/2 of 8.2 h .…”
Section: Discussionmentioning
confidence: 99%