The stem cell renewal and DNA damage response pathways are frequently altered in fibroepithelial tumors of breast in Indian patients

Mukherjee, Nupur; Islam, Md. Saimul; Roychowdhury, Anirban; Bhattacharya, R.K.; Chunder, Nilanjana; Bhattacharya, Nilanjana; Sinha, Satyabrata; Alam, Neyaz; Roy, Anup; Roychoudhury, Susanta; Panda, Chinmay Kumar

doi:10.1016/j.prp.2015.12.008

Cited by 5 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A widely accepted hallmark of cancer is genomic instability which is manifested possibly due to combined effect of DNA damage, tumour‐specific DNA repair defects, and more recently in the context of genetic/epigenetic control of DNA repair pathways in CSCs . An optimistic scenario is such aberration in DNA damage response pathway may also turn out as a platform for therapeutic opportunities . Further, Al‐Assar et al .…”

Section: Dna Repair Pathway and Drug Resistancementioning

confidence: 99%

Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack

Nilendu

Kumar

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

Cancer stem cells (CSCs) are found in many cancer types, including breast carcinoma. Breast cancer stem cells (BCSCs) are considered as seed of cancer formation and they are associated with metastasis and genotoxic drug resistance. Several studies highlighted the presence of BCSCs in tumor microenvironment and they are accentuated with several carcinoma events including metastasis and resistance to genotoxic drugs and they also rebound after genotoxic burn. Stemness properties of a small population of cells in carcinoma have provided clues regarding the role of tumor microenvironment in tumor pathophysiology. Hence, insights in cancer stem cell biology with respect to molecular signaling, genetics and epigenetic behavior of CSCs have been used to modulate tumor drug resistance due to genotoxic drugs and signaling protein inhibitors. This review summarizes major scientific breakthroughs in understanding the contribution of BCSCs towards tumor's capability to endure destruction inflicted by molecular as well as genotoxic drugs.

show abstract

Section: Dna Repair Pathway and Drug Resistancementioning

confidence: 99%

Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack

Nilendu

Kumar

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin Y654 are associated with breast carcinoma: Clinical and prognostic significance

Mukherjee

Dasgupta

Bhattacharya

et al. 2016

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

Transcriptional activation of β-catenin is a hallmark of Wnt/β-catenin pathway activation. The MCC (Mutated in colorectal cancers) and CTNNBIP1 (catenin, beta interacting protein 1) are two candidate genes which inhibit the transcriptional activity of nuclear β-catenin. The importance of MCC and CTNNBIP1 in breast cancer (BC) development has not yet been studied in detail. For this reason, in present study, the alterations (deletion/methylation/mutation/expression) of MCC and CTNNBIP1 were analyzed in BC of Indian patients (N=120) followed by expression/mutation analysis of β-catenin. Then transcriptional activity of β-catenin was checked by expression analysis of its target genes (EGFR, C-MYC and CCND1) in the same set of samples. Frequent methylation (44-45%) than deletion (20-32%) with overall alterations of 52-55% was observed in MCC/CTNNBIP1 in the BC samples. The alterations of MCC/CTNNBIP1 showed significant correlation with increased nuclear β-catenin/p-β-catenin(Y654) expression. Also, a significant correlation was seen between nuclear β-catenin expression and overexpression of its target genes like EGFR, MYC and CCND1 in the BC samples (P<0.0001). An upregulation of MCC and CTNNBIP1 expression by 5-Aza-2'-deoxycytidine treatment of MCF7 and MDA-MB-231 cell lines lead to downregulation of β-catenin and its target genes. The expression of nuclear p-β-catenin(Y654), EGFR, MYC and CCND1 were significantly high in TNBC (Triple negative BC) and Her2+ compared to Luminal A/B+ subtypes. The TNBC patients in stage III/IV having reduced expression of MCC in the tumors showed poor prognosis. Thus, our data suggests that inactivation of MCC/CTNNBIP1 could be an important event in activation of β-catenin mediated transcription of target genes in BC.

show abstract

Wnt/β-Catenin Signaling Pathway as Chemotherapeutic Target in Breast Cancer: An Update on Pros and Cons

Mukherjee

Panda

2020

Clinical Breast Cancer

View full text Add to dashboard Cite

The stem cell renewal and DNA damage response pathways are frequently altered in fibroepithelial tumors of breast in Indian patients

Cited by 5 publications

References 43 publications

Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack

Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack

Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin Y654 are associated with breast carcinoma: Clinical and prognostic significance

Wnt/β-Catenin Signaling Pathway as Chemotherapeutic Target in Breast Cancer: An Update on Pros and Cons

Contact Info

Product

Resources

About