The stem cell zoo for comparative studies of developmental tempo

Lázaro, Jorge; Sochacki, Jaroslaw; Ebisuya, Miki

doi:10.1016/j.gde.2023.102149

Current Opinion in Genetics & Development

2024

DOI: 10.1016/j.gde.2023.102149

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The stem cell zoo for comparative studies of developmental tempo

Jorge Lázaro,

Jaroslaw Sochacki,

Miki Ebisuya

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2024

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Cited by 2 publications

References 68 publications

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Ethical assessment of genome resource banking (GRB) in wildlife conservation

Biasetti,

Mercugliano,

Schrade

et al. 2024

Cryobiology

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Ethical assessment of genome resource banking (GRB) in wildlife conservation

Biasetti,

Mercugliano,

Schrade

et al. 2024

Cryobiology

View full text Add to dashboard Cite

Compensation of gene dosage on the mammalian X

Cecalev,

Viçoso,

Galupa

2024

Development

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Changes in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they can also lead to gene dysregulation and pathologies. Sex chromosomes are a paradigmatic example of naturally occurring gene dosage differences and their compensation. In species with chromosome-based sex determination, individuals within the same population necessarily show ‘natural’ differences in gene dosage for the sex chromosomes. In this Review, we focus on the mammalian X chromosome and discuss recent new insights into the dosage-compensation mechanisms that evolved along with the emergence of sex chromosomes, namely X-inactivation and X-upregulation. We also discuss the evolution of the genetic loci and molecular players involved, as well as the regulatory diversity and potentially different requirements for dosage compensation across mammalian species.

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The stem cell zoo for comparative studies of developmental tempo

Cited by 2 publications

References 68 publications

Ethical assessment of genome resource banking (GRB) in wildlife conservation

Ethical assessment of genome resource banking (GRB) in wildlife conservation

Compensation of gene dosage on the mammalian X

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