The Sterochemistry of Square Complexes.

Mellor, D. P.

doi:10.1021/cr60105a003

Cited by 35 publications

(16 citation statements)

References 65 publications

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“…The Ad-functionalized en derivative L ( Fig. 1) was used as a bifunctional ligand that can bind to ␤CD via hydrophobic inclusion of the Ad moiety and to suitable metal ions via bidentate coordination of the en moiety (47). The synthesis of L and its interaction with unmodified ␤CD and with ␤CD SAMs has been described (46).…”

Section: Resultsmentioning

confidence: 99%

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Intravesicular and intervesicular interaction by orthogonal multivalent host–guest and metal–ligand complexation

Lim

Crespo-Biel

Stuart

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Host vesicles composed of amphiphilic ␤-cyclodextrin CD1 recognize metal-coordination complexes of the adamantyl-functionalized ethylenediamine ligand L via hydrophobic inclusion in the ␤-cyclodextrin cavities at the vesicle surface. In the case of Cu(II) and L, the resulting coordination complex was exclusively CuL2, and the interaction with the host vesicles was intravesicular, unless the concentration of metal complex and vesicles was high (>0.1 mM). In the case of Ni(II) and L, a mixture was formed consisting of mainly NiL and NiL2, the interaction with the host vesicles was effectively intervesicular, and addition of the guest-metal complex resulted in aggregation of the vesicles into dense, multilamellar clusters even in dilute solution [1 M Ni(II)]. The metal-L complex could be eliminated by a strong chelator such as EDTA, and the intervesicular interaction could be suppressed by a competitor such as unmodified ␤-cyclodextrin. The result from this investigation is that the strongest metal-coordination complex [Cu(II) with L] binds exclusively intravesicularly, whereas the weakest metal-coordination complex [Ni(II) with L] binds predominantly intervesicularly and is the strongest interfacial binder. These experimental observations are confirmed by a thermodynamic model that describes multivalent orthogonal interactions at interfaces.self-assembly ͉ vesicles ͉ cyclodextrins M ultivalent, noncovalent interactions at the interface of cell membranes are involved in a variety of biological processes such as cell-cell signaling, pathogen identification, and inflammatory response (1). Multivalent binding events have collective properties that are qualitatively and quantitatively different from the contributing monovalent interactions. For example, multivalent interactions lead to higher binding affinities and can afford larger contact areas between surfaces (1-3). Multivalency can be conveniently described by an effective concentration (C eff ) term that represents a probability of interaction between two interlinked reactive or complementary entities and symbolizes the concentration of one of the reacting or interacting functionalities as experienced by its counterpart (4, 5). Versatile model systems to investigate multivalent noncovalent interactions at the dynamic interface between cell membranes and the surrounding aqueous solution include self-assembled monolayers (SAMs) (6-11), nanoparticles (12-14), solid-supported lipid bilayers (15, 16), and bilayer vesicles (17-19).Metal-ligand coordination has been exploited to generate complex molecular architectures with specific topology, high stability, and original properties in aqueous solution (16,20,21). The N-nitrilotriacetic acid-histidine interaction is particularly interesting in a biological context. N-nitrilotriacetic acidfunctionalized lipids (22, 23) and SAMs (24, 25) have been used to immobilize proteins through multivalent interactions. In a comparable approach, the multivalent binding of Cu(II) ions to a membrane-bound dansyl-ethylenediamine conjugat...

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Section: Resultsmentioning

confidence: 99%

“…Cu(II) forms divalent coordination complexes with en and en derivatives with a square-planar geometry (47). The cis and trans configurations (Fig.…”

Section: Resultsmentioning

confidence: 99%

Intravesicular and intervesicular interaction by orthogonal multivalent host–guest and metal–ligand complexation

Lim

Crespo-Biel

Stuart

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…Both :Ni++ and pd++ form square, quadricovalent complexes, and part of the specificity of dimethylglyoxime can be accounted for by the relatively few divalent ions with square covalence. Mellor (1943) lists known square complexes of Pt++, Fe++, Co++, Mn ++, Cu ++ and Ag++. However, for most of these it is easy to keep the metal in another oxidation state, and for some the tendency to form octahedral complexes is so great that square complexes are obtainable only under special circumstances.…”

Section: Introductionmentioning

confidence: 99%

The structure of nickel dimethylglyoxime

Godycki¹,

Rundle²

1953

Acta Cryst

249

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“…In 1944, Michele Peyrone first synthesized cisplatin, though its structure was still unknown till that date. After 50 years, Alfred Warner proposed its square planar geometry and its isomers (Mellor, 1943). The early method of synthesis needed some improvements for better yield, purity, and reaction time.…”

Section: Synthesis Of Cisplatinmentioning

confidence: 99%

Therapeutics: Key to well being

2021

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The Sterochemistry of Square Complexes.

Cited by 35 publications

References 65 publications

Intravesicular and intervesicular interaction by orthogonal multivalent host–guest and metal–ligand complexation

Intravesicular and intervesicular interaction by orthogonal multivalent host–guest and metal–ligand complexation

The structure of nickel dimethylglyoxime

Therapeutics: Key to well being

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