The sticky business of adhesion prevention in minimally invasive gynecologic surgery

Han, Esther; Scheib, Stacey A.; Patzkowsky, K.E.; Simpson, Khara; Wang, Karen C.

doi:10.1097/gco.0000000000000372

Cited by 19 publications

(26 citation statements)

References 82 publications

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“…Second, there is a method of suppressing adhesion using drugs based on the mechanism of adhesion [ 128 ]. Finally, there is a method of minimizing adhesion by unnecessary tissue damage by using delicate surgery and minimally invasive surgery [ 129 ]. However, whilst minimally invasive surgical techniques can help to prevent adhesion to a level that minimizes or prevents exposure to foreign substances and tissue drying, there is the limitation that adhesion cannot be eliminated.…”

Section: Various Strategies Of Anti-adhesionmentioning

confidence: 99%

Biomaterials to Prevent Post-Operative Adhesion

et al. 2020

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Surgery is performed to treat various diseases. During the process, the surgical site is healed through self-healing after surgery. Post-operative or tissue adhesion caused by unnecessary contact with the surgical site occurs during the normal healing process. In addition, it has been frequently found in patients who have undergone surgery, and severe adhesion can cause chronic pain and various complications. Therefore, anti-adhesion barriers have been developed using multiple biomaterials to prevent post-operative adhesion. Typically, anti-adhesion barriers are manufactured and sold in numerous forms, such as gels, solutions, and films, but there are no products that can completely prevent post-operative adhesion. These products are generally applied over the surgical site to physically block adhesion to other sites (organs). Many studies have recently been conducted to increase the anti-adhesion effects through various strategies. This article reviews recent research trends in anti-adhesion barriers.

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Section: Various Strategies Of Anti-adhesionmentioning

confidence: 99%

Biomaterials to Prevent Post-Operative Adhesion

et al. 2020

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“…There is great interest in new adhesion prevention technologies [28]. In order to evaluate the risk of toxic effects of prophylactic agents, we suggest the use of multiple tests using blood and urine specimens, not only to detect changes in the systemic inflammatory response, but also to assess the possibility of clinically important adverse effects on the renal, hepatic and hematopoietic systems.…”

Section: Recommendationsmentioning

confidence: 99%

Practical considerations in the use of a porcine model (Sus scrofa domesticus) to assess prevention of postoperative peritubal adhesions

Crispi¹,

Mendes

Andrade³

et al. 2020

PLoS ONE

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Funding: This study was supported by DMC Importação e Exportação de Equipamentos Ltda which provided advanced medical devices and equipment for surgical procedures through its product development centers and manufacturing facilities in São Carlos-SP, Brazil, and by Instituto Crispi de Cirurgias Minimamente Invasivas (Rio de and measures that can help to minimize animal suffering and avoid problems during such experiments.

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“…A strong deterrent for using a solid adhesion barrier in patients with metabolic syndrome and therefore a proinflammatory state is the risk for rejection. There is, however, no real proof of the clinical benefit of flowable/liquid adhesion barriers over saline or other crystalloid solutions [34,35]. A different approach towards adhesion prevention is to attempt to use existing and approved pharmacological agents such as steroids [36,37] , and systemically applied antibiotic treatment [38,39].…”

Section: How Can We Better Manage Surgical Adhesion Prophylaxis In Pamentioning

confidence: 99%

Metabolic Syndrome is a Risk Factor for Post-Operative Adhesions: Need for Novel Treatment Strategies

Pilpel¹,

Pines

Birkenfeld

et al. 2018

Horm Metab Res

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Metabolic syndrome is a group of disorders which include obesity, diabetes, dyslipidemias, and hypertension. This condition is rapidly increasing in an aging population. The rates of surgery in older patients is also growing and a wide range of operations including minimally invasive procedures is now available for this segment of the population. The number of patients suffering from postoperative adhesions is therefore correspondingly increasing. In addition to preventing and treating the metabolic disease itself, improved therapeutic strategies for the prevention of surgical adhesions have to be developed. Here we review the existing and novel treatment options.

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The sticky business of adhesion prevention in minimally invasive gynecologic surgery

Abstract: There is great interest in new adhesion prevention technologies, but new agents are unlikely to be available for clinical use for many years. High-quality effectiveness and outcomes-related research is still needed.

Cited by 19 publications

References 82 publications

Biomaterials to Prevent Post-Operative Adhesion

Biomaterials to Prevent Post-Operative Adhesion

Practical considerations in the use of a porcine model (Sus scrofa domesticus) to assess prevention of postoperative peritubal adhesions

Metabolic Syndrome is a Risk Factor for Post-Operative Adhesions: Need for Novel Treatment Strategies

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