The stimulation of the eosinophil leucocyte

Vaughn, John

doi:10.1002/path.1700640111

Cited by 30 publications

(10 citation statements)

References 22 publications

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“…These studies have established that histamine can regularly bring about a prompt and substantial eosinophilia at extravascular sites, but the reaction is related to the hydrogen ion concentration of the solution and not to any other (unique) property of histamine. Previous experiments had demon strated that histamine can provoke systemic eosinophilia [17,18], and the present experiments provide still another confirmation. However, in the past, extravascular eosinophilia had been elicited only by unnaturally large doses [3,9].…”

Section: Systemic Eosinophilia Following Intraperitoneal Histaminesupporting

confidence: 79%

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Studies in Experimental Eosinophilia

Litt¹

1976

Int Arch Allergy Immunol

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A solution of histamine in saline elicited an eosinophil response in both lymph nodes and the blood stream. The lymph node response was not inhibited by the antihistamine, mepyramine maleate, but was inhibited by puromycin. Both the lymph node and the systemic response were essentially abolished when the pH of the solution (5.0 and 4.7, respectively) was brought to neutrality by phosphate buffer. Serum could bring the pH of histamine to neutrality or higher, but the histamine-serum mixture retained in vivo activity, unless the histamine was buffered before addition to the serum. When normal guinea pig γ-globulin was incubated with histamine, a nondialyzable factor was generated which had the same activity as histamine. Thirteen different amino acids induced lymph node eosinophilia and each was acid in saline solution; when one of them, tryptophane, was brought to neutral pH, its activity was considerably reduced. During the period when the circulating level of eosinophils was rising, there was no detectable fall in the bone marrow stores of mature or immature eosinophils. Thus, the activity of histamine, vis-à-vis eosinophils, is nonspecific and is attributable to its acidity. The data suggest that histamine, in the acidic state, generates autoantigens, which, in turn, lead to antibody-mediated eosinophilia in lymph nodes.

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Section: Systemic Eosinophilia Following Intraperitoneal Histaminesupporting

confidence: 79%

“…The experiments reported in this paper cast doubt on this supposition. In previous studies [9,13], we had confirmed Va u g h n 's observation [17,18] that histamine brings eosinophils into the blood stream; it does not. however, mediate local eosinophilia.…”

Section: Introductionsupporting

confidence: 75%

Studies in Experimental Eosinophilia

Litt¹

1976

Int Arch Allergy Immunol

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“…-ParazitIerin e o s i n o p h i 1 i a yapış mekanizmasını da. bir çok araştırıcılar, bunların toksinleri ve uzviyette uzun zaman kalmalan ile allerjik durum yaratmalarına a.tfediyorlar (13,81,85).…”

Section: Ortalama Korpüsküler Hemoglobin Konsantrasyonu Bir Anemininunclassified

TRAKYA BÖLGESİNDEK! NORMAL BOZ - ffiK İNEKLERİN HEMOGRAM

Noyan¹

1959

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Campbell and co-workers concluded that eosinophilia does not occur in the absence of hyper sensitivity. Eosinophilia can be elicited by histamine (Berger and Lang, 1931) and the eosinophilia produced by extracts of Ascaris suum can be prevented by the administration of antihistamine drugs (Vaughn, 1952). Letterer (1956) remarks that "neither the absence nor the presence of eosinophilia speaks with certainty for or against an allergic hypersensitivity reaction; on the other hand its presence is good ground for suspicion".…”

Section: A Cellular Components -The Eosinophil Cellmentioning

confidence: 99%