PT XYZ is a company operating in the tire retreading sector on JL. Medan-Banda Aceh, Cot Seurani Village, Muara Batu District, Aceh Utara. Retreading truck tires is carried out through several processes such as inspection, grating, repairing, gluing tire, installing tire treads, installing wheels and rings, cooking tires and finishing. The vulcanization process which is carried out manually and repeatedly makes workers easily fatigued, making them vulnerable to injury and the risk of Musculoskeletal Disorders (MSDs). This research aims to calculate the workload of PT XYZ workers. PT XYZ to determine the level of worker fatigue using the Energy Expenditure approach and assessing worker work posture using the BRIEF method to assess work postures that cause complaints of pain in workers’ body parts. Researchers measured the resting pulse and working pulse of 8 workers, then classified the Cardiovascular Load (%CVL) and Energy Expenditure workload levels of the workers and assessed work posture using the BRIEF worksheet. The results of calculating the worker’s workload obtained an average %CVL value of 57.92%, the average result of the worker’s Energy Expenditure was 6,8048 Kcal/8 hours with very heavy work criteria. The average BRIEF work posture value is 3.28 in the high risk category. The suggestions given regarding the problem of workers who easily experience fatigue, high workloads and unergonomic work postures are to increase the number of workers, add benchrest jacks at each work station, add a table with wheels and rings and add chairs for finishing workers, lighten the work and reduce excessive bending activities for tire retreading workers.