The strain of unfamiliar conspecifics affects stress identification in rats

Kiyokawa, Yasushi; Kuroda, Naoko; Takeuchi, Yukari

doi:10.1016/j.beproc.2022.104714

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…However, most analyses of play in F344 rats have involved testing them in dyads with partners from other strains, and even though still relatively low, in the cases in which F344–F344 pairs were tested, the number of playful attacks was greater (Siviy et al., 1997, 2003, 2011, 2017, 2023), suggesting that F344 rats play more together than when playing with partners from different strains. Indeed, as adults, LE, Sprague–Dawley, and Wistar rats prefer their own strain but will readily associate with one of the other strains before settling for a F344 partner if that is the only option available (Kiyokawa et al., 2022; Kogo et al., 2021). These findings suggest that F344 rats are so different from other strains that they are unattractive as play partners, as other strains are to them.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, as adults, LE, Sprague-Dawley, and Wistar rats prefer their own strain but will readily associate with one of the other strains before settling for a F344 partner if that is the only option available (Kiyokawa et al, 2022;Kogo et al, 2021). These findings suggest that F344 rats are so different from other strains that they are unattractive as play partners, as other strains are to them.…”

Section: 3mentioning

confidence: 97%

“…Given that role reversals seem to be particularly important experiences derived from play fighting that contribute to facilitating the development of sociocognitive skills (Pellis et al., 2019), even if the amount of play of F344 rats were increased by interacting with LE peers, the quality of the play may not. Rat strains such as LE, Wistar, and Sprague–Dawley seem to be particularly averse to interacting with F344 rats (Kiyokawa et al., 2022; Kogo et al., 2021). Perhaps, as the former three strains are more closely related to each other than any are to F344 (Lindsey & Baker, 2006), they may not be perceived as compatible partners.…”

Section: Introductionmentioning

confidence: 99%

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Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits

Ham,

Szabo,

Annor‐Bediako

et al. 2024

Developmental Psychobiology

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Reduced play experience over the juvenile period leads to adults with impoverished social skills and to anatomical and physiological aberrations of the neurons found in the medial prefrontal cortex (mPFC). Even rearing rats from high‐playing strains with low‐playing strains show these developmental consequences. In the present study, we evaluated whether low‐playing rats benefit from being reared with higher playing peers. To test this, we reared male Fischer 344 rats (F344), typically thought to be a low‐playing strain, with a Long–Evans (LE) peer, a relatively high‐playing strain. As juveniles, F344 rats reared with LE rats experienced less play and lower quality play compared to those reared with another F344. As adults, the F344 rats reared with LE partners exhibited poorer social skills and the pyramidal neurons of their mPFC had larger dendritic arbors than F344 rats reared with same‐strain peers. These findings show that being reared with a more playful partner does not improve developmental outcomes of F344 rats, rather the discordance in the play styles of F344 and LE rats leads to poorer outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: 3mentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits

Ham,

Szabo,

Annor‐Bediako

et al. 2024

Developmental Psychobiology

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“…Animals show distinct social behaviors when they evaluate an individual as to whether it is a member of the same group and recognize social similarity to that individual. In rats, the strain can serve as the group with regard to recognizing social similarity (Ben-Ami Bartalet al , 2014;Han et al , 2019;Kogo et al , 2021;Kiyokawa et al , 2022). We previously found that social buffering is affected by the strain of associates (Nakamura et al , 2016).…”

Section: Discussionmentioning

confidence: 99%

Naloxone blocks social buffering of conditioned fear responses in rats

Yamasaki

Kiyokawa

Munetomo

et al. 2023

Preprint

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Social buffering is the phenomenon in which the presence of an affiliative conspecific mitigates stress responses. We previously demonstrated that social buffering completely ameliorates conditioned fear responses in rats. The present study explored the neurochemical background of this social buffering. In Experiment 1, fear-conditioned subjects first received an intraperitoneal injection of either naloxone (non-selective opioid receptor antagonist), haloperidol (dopamine D2 receptor antagonist), SR49059 (vasopressin V1A receptor antagonist), atosiban (oxytocin receptor antagonist), or saline. The subjects were then exposed to a conditioned stimulus with an unfamiliar non-conditioned rat. Naloxone, but not the other three antagonists, blocked social buffering. In Experiment 2, we assessed the effect of naloxone on locomotor activity during an open-field test. Naloxone did not affect walking steps during the test. Therefore, it is unlikely that the results of Experiment 1 were due to decreased activity by naloxone. In Experiment 3, we assessed Fos expression in 16 brain regions accompanied by the blockade of social buffering by naloxone. Consistent with the results of Experiment 1, Fos expression was increased in the paraventricular nucleus of the hypothalamus. In addition, Fos expression was decreased in the nucleus accumbens shell, anterior cingulate cortex, and insular cortex and tended to be decreased in the nucleus accumbens core. Naloxone thus appears to affect these four regions and/or act upstream of these regions during blockade of social buffering. Based on these results, we conclude that naloxone blocks social buffering of conditioned fear responses in rats.

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“…Social interaction might be assessed in a couple of freely moving animals, placed in a simple or enriched context [ 12 , 29 , 30 , 31 ]. Alternatively, “guest” animals might be fixed with tether and collar assemblies [ 30 , 32 ], separated in a compartment of the test arena [ 33 , 34 , 35 ], or encaged [ 36 , 37 , 38 ]. The social stimuli might be isolated by partitions, which specifically limit or restrict visual, audial, haptic, or olfactory sensory inputs involved in animal interactions [ 39 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

Rebik,

Broshevitskaya,

Kuzhuget

et al. 2023

Biomedicines

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Epilepsy or epileptic syndromes affect more than 70 million people, often comorbid with autism spectrum disorders (ASD). Seizures are concerned as a factor for social regression in ASD. A stepwise experimental approach to this problem requires an animal model to provoke seizures and monitor subsequent behavior. We used rats of the Krushinsky–Molodkina (KM) strain as a validated inbred genetic model for human temporal lobe epilepsy, with recently described social deficiency and hypolocomotion. Generalized tonic-clonic seizures in KM rats are sound-triggered, thus being controlled events in drug-naïve animals. We studied whether seizure experience would aggravate contact deficits in these animals. Locomotor and contact parameters were registered in “the elevated plus maze”, “socially enriched open field”, and “social novelty/social preference tests” before and after sound-provoked seizures. The triple seizure provocations minimally affected the contact behavior. The lack of social drive in KM rats was not accompanied by a submissive phenotype, as tested in “the tube dominance test”, but featured with a poor contact repertoire. Here, we confirmed our previous findings on social deficits in KM rats. The contact deficiency was dissociated from hypolocomotion and anxiety and did not correlate with seizure experience. It was established that experience of rare, generalized tonic-clonic convulsions did not lead to an impending regress in contact motivation, as seen in an animal model of genetic epilepsy and comorbid social deficiency. One of the oldest animal models for epilepsy has a translational potential to study mechanisms of social behavioral deficits in future neurophysiological and pharmacological research.

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The strain of unfamiliar conspecifics affects stress identification in rats

Cited by 6 publications

References 36 publications

Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits

Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits

Naloxone blocks social buffering of conditioned fear responses in rats

Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

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