“…Increased falls and fracture risks were reported in patients with combination of sarcopenia and OP [ 483 , 506 , 507 ], but, surprisingly, a synergistic effect has not been observed in community-dwelling older men [ 508 ]. Noticeable, RFs for falls linked with HPI-related morbidity include, in addition to altered muscle status, impaired vision, hemodynamic instability (orthostatic and postprandial hypotension), arrhythmias, mental impairment, depression and anxiety [ 457 , 466 , 468 , 509 , 510 ], as well as the numerous medications used. Strong associations between frailty and an increased propensity to falls, fractures and mortality are well documented [ 483 , 511 , 512 , 513 , 514 , 515 , 516 , 517 , 518 , 519 , 520 ].…”