The strength of feedback processing is associated with resistance to visual backward masking during Illusory Contour processing in adult humans

Foxe, John J.; Knight, Emily; Myers, Evan J; Cao, Cody Zhewei; Molholm, Sophie; Freedman, Edward G.

doi:10.1016/j.neuroimage.2022.119416

Cited by 2 publications

(1 citation statement)

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“…Extracting features matches the selectivity of V1 neurons [ 39 ]. Combining these features into an object involves linking these features, a process where the response of V1 neurons by re-entrant projections originating in extra-striate cortex [ [40] , [41] , [42] ]. Extraction of features and ‘object closure’ both involve a mechanism selective to spatial luminance contrast, i.e.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the neuronal response in human primary visual cortex by re-entrant projections during retinal input processing as manifest in the visual evoked potential

Marcar,

Wolf

2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Modulation of the neuronal response in human primary visual cortex by re-entrant projections during retinal input processing as manifest in the visual evoked potential

Marcar,

Wolf

2024

Heliyon

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It’s all in the timing: delayed feedback in autism may weaken predictive mechanisms during contour integration

Knight,

Altschuler,

Molholm

et al. 2024

Journal of Neurophysiology

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Humans rely on predictive mechanisms during visual processing to efficiently resolve incomplete or ambiguous sensory signals. While initial low-level sensory data are conveyed by feedforward connections, feedback connections are believed to shape sensory processing through conveyance of statistical predictions based on prior exposure to stimulus configurations. Individuals with autism spectrum disorder (ASD) show biases in stimulus processing toward parts rather than wholes, suggesting their sensory processing may be less shaped by statistical predictions acquired through prior exposure to global stimulus properties. Investigations of illusory contour (IC) processing in neurotypical (NT) adults have established a well-tested marker of contour integration characterized by a robust modulation of the visually evoked potential (VEP) - the IC-effect - that occurs over lateral occipital scalp during the timeframe of the N1 component. Converging evidence strongly supports the notion that this IC-effect indexes a signal with significant feedback contributions. Using high-density VEPs, we compared the IC-effect in 6-7-year-old children with ASD (n=32) or NT development (n=53). Both groups of children generated an IC-effect that was equivalent in amplitude. However, the IC-effect notably onset 21ms later in ASD, even though initial VEP afference was identical across groups. This suggests that feedforward information predominated during perceptual processing for 15% longer in ASD compared to NT children. This delay in the feedback dependent IC-effect, in the context of known developmental differences between feedforward and feedback fibers, suggests a potential pathophysiological mechanism of visual processing in ASD, whereby ongoing stimulus processing is less shaped by statistical prediction mechanisms.

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The strength of feedback processing is associated with resistance to visual backward masking during Illusory Contour processing in adult humans

Cited by 2 publications

References 46 publications

Modulation of the neuronal response in human primary visual cortex by re-entrant projections during retinal input processing as manifest in the visual evoked potential

Modulation of the neuronal response in human primary visual cortex by re-entrant projections during retinal input processing as manifest in the visual evoked potential

It’s all in the timing: delayed feedback in autism may weaken predictive mechanisms during contour integration

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