2018
DOI: 10.1523/jneurosci.2793-17.2017
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The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex

Abstract: The energetic costs of behavioral chronic stress are unlikely to be sustainable without neuronal plasticity. Mitochondria have the capacity to handle synaptic activity up to a limit before energetic depletion occurs. Protective mechanisms driven by the induction of neuronal genes likely evolved to buffer the consequences of chronic stress on excitatory neurons in prefrontal cortex (PFC), as this circuitry is vulnerable to excitotoxic insults. Little is known about the genes involved in mitochondrial adaptation… Show more

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Cited by 71 publications
(64 citation statements)
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“…This could explain differential modulation of GR activity in mesolimbic and corticolimbic networks. Deletion of GR phosphorylation sites in neurons belonging to corticolimbic brain areas interferes with the expression of GR-regulated target genes involved in cytoskeleton dynamics, mitochondrial functions, synapse formation and maintenance (62,68,69). What's more, BDNF-dependent GR phosphorylation sites reside near a caspase-1 site, whose cleavage causes partial loss of GR transcriptional activity in animal models and a disease of glucocorticoid resistance in humans (70,71).…”
Section: Effect Of Bdnf and Glucocorticoid Signaling In Health And DImentioning
confidence: 99%
“…This could explain differential modulation of GR activity in mesolimbic and corticolimbic networks. Deletion of GR phosphorylation sites in neurons belonging to corticolimbic brain areas interferes with the expression of GR-regulated target genes involved in cytoskeleton dynamics, mitochondrial functions, synapse formation and maintenance (62,68,69). What's more, BDNF-dependent GR phosphorylation sites reside near a caspase-1 site, whose cleavage causes partial loss of GR transcriptional activity in animal models and a disease of glucocorticoid resistance in humans (70,71).…”
Section: Effect Of Bdnf and Glucocorticoid Signaling In Health And DImentioning
confidence: 99%
“…and Npas4 are known to be necessary for synaptic plasticity and memory 16,[54][55][56][57][58][59][60][61] . Moreover, the essential roles of CREB, MEF2 and SRF in memory storage have been proven beyond any doubt 2,14,[62][63][64] .…”
Section: Discussionmentioning
confidence: 99%
“…Mice at 3-months of age were subjected to tail suspension test (TST) for 6 min during the stress protocol (once a week between PND 23 and 36) and video recorded trial. Trial data represent an acquired behavioral response in the stress groups but a novel response in the control groups reared in standard living conditions (65).…”
Section: Methodsmentioning
confidence: 99%