The stressed gut: Contributions of intestinal stress peptides to inflammation and motility

Bunnett, Nigel W.

doi:10.1073/pnas.0503092102

Cited by 21 publications

(14 citation statements)

References 15 publications

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“…The BN and NMC have L-leucine (Leu) as the penultimate residue, the ranatensins (NMB and PG-L) have Lphenylalanine (Phe) as the penultimate residue, and the phyllolitorins have L-serine (Ser) as the 3rd residue from the carboxyl terminus. The mammalian bombesin-like peptides mediate a spectrum of biological activities in the central nervous system and peripheral tissues 18,19 including thermoregulation, 20 nociception, 21 the regulation of smooth muscle contraction, 21 satiety, 22 control of circadian rhythms, 23 stimulation of pancreatic and gastrointestinal hormone secretion, 24 macrophage activation, 25 and neuronal firing rate by binding to structurally and pharmacologically distinct receptors. 26 These peptides also have important developmental effects 27 and potent growth effects on both normal and neoplastic cells, 28,29 causing proliferation of normal cells 28 and various tumor cell lines (small lung cancers, prostate, gastric, pancreatic, colon, and breast carcinomas).…”

Section: Introductionmentioning

confidence: 99%

“…ombesin (BN), gastrin releasing peptide (GRP), and its 18-27 fragment of amino acid sequence: neuromedin C (NMC or GRP [18][19][20][21][22][23][24][25][26][27] ), neuromedin B (NMB), phyllolitorin, and pseudophyrene guntheri (PG-L) are small amidated peptides that belong to a family of peptides initially isolated from frog skin. 1 These have been found to be widely distributed in the central nervous system, the lung and the gut.…”

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confidence: 99%

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Structural properties of bombesin‐like peptides revealed by surface‐enhanced Raman scattering on roughened silver electrodes

Podstawka

2008

Biopolymers

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This work presents a Fourier-transform absorption infrared, Fourier-transform Raman, and surface-enhanced Raman scattering (SERS) study of the following peptides belonging to the bombesin-like family: phyllolitorin, [Leu(8)]phyllolitorin, NMB, NMC, and PG-L. The SERS study was undertaken to understand the adsorption mechanism of bombesin-like peptides on an electrochemically roughened silver electrode surface and to show changes in the adsorption mechanism with alterations in amino acids and small tertiary structures. The SERS spectra presented here shows bands mainly associated with the Trp(8) residue vibrations. The presence of mainly pyrrole coring vibrations for phyllolitorin and [Leu(8)]phyllolitorin and mainly benzene coring modes for NMB and NMC indicated that these groups interact with the roughened silver electrode surface. Furthermore, N(1)-C(8) and C(3)-C(9) bonds of the PG-L indole ring seemed to have nearly a vertical orientation on the electrode surface. In addition, distinct vibrations of the C-S fragment were observed in the SERS spectra of [Leu(8)]phyllolitorin and PG-L. The strong enhancement of the nu(C=O) vibration in the [Leu(8)]phyllolitorin SERS spectrum yielded evidence that the intact C=O bond(s) bind strongly to the silver electrode surface, whereas NMC, phyllolitorin, and NMB were located near the silver surface. This finding was supported by the presence of the nu(C-C(=O)) mode. The amide I band observed at 1642 and 1634 cm(-1) for NMB and NMC, respectively, and the Raman amide III band seen in the 1282-1249 cm(-1) range for all peptides except PG-L, indicate that the strongly hydrogen-bonded alpha-helical conformation and random-coil structure are favored for binding to the surface.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Structural properties of bombesin‐like peptides revealed by surface‐enhanced Raman scattering on roughened silver electrodes

Podstawka

2008

Biopolymers

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“…This effect of stress is probably mediated by the sympathomedullary system and corticotrophin-releasing factor (CRF) acting both centrally and within the gut (Bunnett 2005, Tache et al 2008, Lukewich et al 2014. Notwithstanding the possible role of stress in bowel disorders and the fact that CRF and its receptors are regarded by some as potentially relevant therapeutic targets (Tache et al 2008), it must be stressed that the signal factors that trigger IBD and related disorders remain to be determined.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Selye’s general adaptation syndrome: stress-induced gastro-duodenal ulceration and inflammatory bowel disease

Fink

2017

Journal of Endocrinology

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Hans Selye in a note to Nature in 1936 initiated the field of stress research by showing that rats exposed to nocuous stimuli responded by way of a 'general adaptation syndrome' (GAS). One of the main features of the GAS was the 'formation of acute erosions in the digestive tract, particularly in the stomach, small intestine and appendix'. This provided experimental evidence for the view based on clinical data that gastroduodenal (peptic) ulcers could be caused by stress. This hypothesis was challenged by Marshall and Warren's Nobel Prize (2005)-winning discovery of a causal association between Helicobacter pylori and peptic ulcers. However, clinical and experimental studies suggest that stress can cause peptic ulceration in the absence of H. pylori. Predictably, the etiological pendulum of gastric and duodenal ulceration has swung from 'all stress' to 'all bacteria' followed by a sober realization that both factors play a role, separately as well as together. This raises the question as to whether stress and H. pylori interact, and if so, how? Stress has also been implicated in inflammatory bowel disease (IBD) and related disorders; however, there is no proof yet that stress is the primary etiological trigger for IBD. Central dopamine mechanisms seem to be involved in the stress induction of peptic ulceration, whereas activation of the sympathetic nervous system and central and peripheral corticotrophin-releasing factor appears to mediate stress-induced IBD.

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“…We therefore turned to our alternative hypothesis, of altered intestinal physiology mediating the microbiota changes. Similarly to previous reports using stress models 159,160 , intestinal motility was significantly increased in the stressed animals ( Fig. 6a).…”

Section: Microbiota Composition Is Altered By Unpredictable Chronic Msupporting

confidence: 70%

Altered Microbiota Composition Mediates Depressive Behavior During Chronic Stress

Marin¹

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The stressed gut: Contributions of intestinal stress peptides to inflammation and motility

Cited by 21 publications

References 15 publications

Structural properties of bombesin‐like peptides revealed by surface‐enhanced Raman scattering on roughened silver electrodes

Structural properties of bombesin‐like peptides revealed by surface‐enhanced Raman scattering on roughened silver electrodes

Selye’s general adaptation syndrome: stress-induced gastro-duodenal ulceration and inflammatory bowel disease

Altered Microbiota Composition Mediates Depressive Behavior During Chronic Stress

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