The stromal reaction in basal cell carcinomas. A prerequisite for tumour progression and treatment strategy

Bertheim, Ulf; Hofer, Per‐Åke; Engström‐Laurent, Anna; Hellström, Sten

doi:10.1016/j.bjps.2003.12.024

Cited by 15 publications

(20 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro studies support the above evidence indicating the crucial role of HA in the invasiveness of cancer cells, like in breast and colon cancer 18,19 . A recent study indicated that the localization of HA and the proliferative activity of tumour cells differ in various types of BCC 3 . However, to our knowledge, HA homeostasis has not been investigated in full depth in any type of BCC.…”

Section: Introductionsupporting

confidence: 64%

“…Characteristically, in Australia it is three times as common as all other malignancies together 2 . BCC affects mostly Caucasians aged 40–60 years and occurs predominantly on solar exposed skin, especially on the face and neck 3 . Although BCC is considered relatively innocent and is a tumour of low degree of malignancy, if left untreated, it can be locally aggressive, eat away at tissues and cause ulceration.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

Tzellos

Kyrgidis

Vahtsevanos

et al. 2010

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

Section: Introductionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

Tzellos

Kyrgidis

Vahtsevanos

et al. 2010

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…A prominent staining layer is found below the epidermis in the basement membrane (BM) zone. In epidermis HA is concentrated in the intercellular space around the keratinocytes in stratum spinosum and is also distributed in the granular layer (6,13).…”

mentioning

confidence: 99%

Dermal Distribution of Hyaluronan in Psoriatic Arthritis; Coexistence of CD44, MMP3 and 9

Lindqvist¹,

Phil-Lundin²,

Engström‐Laurent³

2012

Acta Derm Venerol

Self Cite

View full text Add to dashboard Cite

Psoriatic arthritis is a chronic systemic disease in which patients develop persistent inflammation of the skin and joints, leading to disability and joint damage. The extracellular component hyaluronan (HA) plays an important role in regulatory processes such as inflammation, wound healing and tumour progression. At any site of inflammation HA can be depolymerized to low-molecular weight fragments, which, in turn, induce an array of inflammatory mediators that can lead to chronic inflammation. This study describes the serum concentration and dermal distribution of HA, its receptor CD44 and the metalloproteinases 3 and 9 in skin biopsies from patients with different types of psoriatic arthritis. Fifty-one patients with psoriatic arthritis were included in the study and classified as oligo- or poly-arthritic PsA with and without treatment. Biopsies were obtained from both involved and non-involved skin and compared with biopsies from healthy individuals. Serum HA was analysed for estimation of the total turnover of HA. The main findings were an overall redistribution of HA in both involved and non-involved psoriatic skin and an epidermal imbalance between HA and CD44. The structurally and functionally important basement membrane zone was found to be disintegrated and devoid of HA irrespective of the type of articular involvement, treatment or skin affection.

show abstract

“…However, certain histological types such as infiltrative or morpheaform BCCs are invasive locally, and can cause serious local damage (1,5). These characteristics suggest the possibility of specific interactions with the surrounding stroma, although their mechanisms involved with regards to tumor proliferation or inhibition in BCC are largely unknown (6,7).…”

Section: Introductionmentioning

confidence: 99%

Probing tumor and peritumoral tissues in superficial and nodular basal cell carcinoma using polarized Raman microspectroscopy

Durlach

Antonicelli

et al. 2009

Experimental Dermatology

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) can sometimes lead, through a possible invasion of the dermis and the subcutaneous tissue, to serious local damage to the patient. Several histological types of BCC are reported, among them, the superficial, nodular and infiltrative forms. This study reports the use of polarized Raman microspectroscopy on the nodular and superficial types to discriminate between healthy epidermis and tumor, and between normal and peritumoral stroma. This technique probes additional information than conventional Raman spectroscopy because it is sensitive to the molecular ordering of tissue components. Depolarization ratios and hierarchical cluster analysis demonstrate that polarized Raman microspectroscopy can better identify the tumor and the peritumoral dermis than conventional Raman microspectroscopy, and hence gives potential complementary data about their molecular characteristics (molecular composition, secondary structure of proteins, intra-and ⁄ or inter-molecular bonding). Our findings also show that although superficial and nodular types of BCC were analysed, clear differences between the spectra of peritumoral and normal dermis could be detected.

show abstract

The stromal reaction in basal cell carcinomas. A prerequisite for tumour progression and treatment strategy

Cited by 15 publications

References 26 publications

Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

Dermal Distribution of Hyaluronan in Psoriatic Arthritis; Coexistence of CD44, MMP3 and 9

Probing tumor and peritumoral tissues in superficial and nodular basal cell carcinoma using polarized Raman microspectroscopy

Contact Info

Product

Resources

About