The structural and functional development of muscle spindles and their connections in fetal sheep

Rees, Sandra; Rawson, John A; Nitsos, Ilias; Brumley, Carolyn

doi:10.1016/0006-8993(94)90921-0

Cited by 12 publications

(4 citation statements)

References 19 publications

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“…Each spindle is comprised of four to nine intrafusal muscle fibers, inner and outer capsules, capillaries and axon terminals of the muscle sensory and fusimotor neurons. The structure, development, and regeneration of the muscle spindle in rodents [7,8], in birds [9], and in sheep [10] are well documented. One of the neurotrophic factors, neurotrophin‐3, is essential for the development and differentiation of both the muscle sensory neuron and the intrafusal muscle fiber [11,12].…”

Section: Discussionmentioning

confidence: 99%

Regulatory expression of MDP77 protein in the skeletal and cardiac muscles

2002

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The mdp77 gene was ¢rst cloned from the cDNA library of denervated chick muscles, while its role(s) in vivo was unknown. In the present study, using speci¢c polyclonal antibodies against MDP77, we show that MDP77 was expressed speci¢cally in the skeletal and cardiac muscle, and con¢rm its presence in the cytoplasm of the extrafusal muscle ¢-bers. In mature muscles, MDP77 immunoreactivity was observed in a repetitive manner along the sarcomere. The onset of MDP77 expression occurred just after myotube formation both in vivo and in vitro. Furthermore, MDP77 was enriched in the intrafusal muscle ¢bers. Our ¢ndings suggest that MDP77 plays an important role(s) in the di¡erentiation, maturation and function of both the skeletal and cardiac muscles.

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Section: Discussionmentioning

confidence: 99%

Regulatory expression of MDP77 protein in the skeletal and cardiac muscles

2002

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“…The free-floating sections were processed according to the method as described (24) to visualize the axons and terminals labeled by biotinylated dextran amine. Phosphate buffer (0.1 M) was the vehicle for the immunoreagents and for rinsing after each of the following steps: (i) incubation in 0.3% hydrogen peroxide in methanol for 20 min to block any endogenous peroxidase activity; (ii) incubation in Avidinperoxidase (Sigma) diluted 1:5,000 in 0.1 M phosphate buffer and 0.75% Triton X-100 for 2 hours; and (iii) processing for horseradish peroxidase histochemistry by using cobaltenhanced diaminobenzidine reaction (25) for 8-10 min.…”

Section: Methodsmentioning

confidence: 99%

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

Dottori

Hartley

Galea

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

273

239

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Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in particular, axon guidance in the developing nervous system. The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and fertile but have a gross motor dysfunction, which is evidenced by a loss of coordination of limb movement and a resultant hopping, kangaroo-like gait. Consistent with the observed phenotype, anatomical studies and anterograde tracing experiments reveal major disruptions of the corticospinal tract within the medulla and spinal cord in the null mutant animals. These results demonstrate a critical role for EphA4 in establishing the corticospinal projection.

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“…The third expectation is that denervation and loss of neurotrophic support from the target is likely to result in a decrease in the number of ␣ 3 Na ϩ ,K ϩ -ATPase peripheral neurons. The structure and innervation of muscle spindles is well studied in developing and adult vertebrate animals, both under control conditions and after axotomy (Barker et al, 1985;Kucera et al, 1988Kucera et al, , 1989Banks, 1994;Rees et al, 1994;Oakley et al, 1995). However, previous studies on the expression of ␣ 3 Na ϩ ,K ϩ -ATPase in vertebrates were mostly limited to evaluation of tissues of normal adult rats, providing no insight into the expression of this isoform during development or in animal models of axotomy (Mata et al, 1993;Zahler et al, 1996;Gerbi et al, 1999;Dobretsov et al, 1999bDobretsov et al, , 2003.…”

mentioning

confidence: 96%

Target‐determined expression of α₃ isoform of the Na⁺,K⁺‐ATPase in the somatic nervous system of rat

Romanovsky

Light

Walker

et al. 2005

J of Comparative Neurology

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Factors that determine the differential expression of isoforms of Na(+),K(+)-ATPase in the nervous system of vertebrates are not understood. To address this question we studied the expression of alpha(3) Na(+),K(+)-ATPase in the L5 dorsal root ganglia (DRG) of developing rat, the normal adult rat, and the adult rat after peripheral axotomy. During development, the first alpha(3) Na(+),K(+)-ATPase-positive DRG neurons appear by embryonic day 21. At birth, the L5 DRG have a full complement (14 +/- 2%) of these neurons. By 15 days after sciatic nerve transection in adult rat, the number of alpha(3) Na(+),K(+)-ATPase-positive DRG neurons and small myelinated L5 ventral root axons decreases to about 35% of control counts. These results combined with data from the literature suggest that the expression of alpha(3) Na(+),K(+)-ATPase by rat somatic neurons is determined by target-muscle spindle-derived factors.

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The structural and functional development of muscle spindles and their connections in fetal sheep

Cited by 12 publications

References 19 publications

Regulatory expression of MDP77 protein in the skeletal and cardiac muscles

Regulatory expression of MDP77 protein in the skeletal and cardiac muscles

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

Target‐determined expression of α₃ isoform of the Na⁺,K⁺‐ATPase in the somatic nervous system of rat

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The structural and functional development of muscle spindles and their connections in fetal sheep

Cited by 12 publications

References 19 publications

Regulatory expression of MDP77 protein in the skeletal and cardiac muscles

Regulatory expression of MDP77 protein in the skeletal and cardiac muscles

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

Target‐determined expression of α3 isoform of the Na+,K+‐ATPase in the somatic nervous system of rat

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Target‐determined expression of α₃ isoform of the Na⁺,K⁺‐ATPase in the somatic nervous system of rat