The bending behavior of one-war reinforced concrete (RC) slabs with polypropylene fibers (PF) was examined in this study under the effect of different opening ratios using the nonlinear finite element analysis (NLFEA) method. The investigated parameters include the effect of different square opening ratios between 0 and 24% and PF volume percentages between 0 and 1% with 0.1% increments. The objectives of this study were fulfilled using 88 NLFEA models with different combinations of the studied parameters, including 11 control slabs without openings. The slab’s behavior was studied focusing on different structural performance characteristics, such as ductility, using energy-based and deflection-based approaches, stiffness (initial and yielding), cracking, and ultimate load strength. In addition, other structural performance parameters were considered, such as the crack opening, failure modes, and strain values, which were recorded for all specimens during the loading history. Moreover, the load-carrying capacity of the slabs was compared, looking at the NLFEA method’s results and the theoretical prediction results based on the sectional analysis method. However, it was observed that the inclusion of PFs of different percentages has a superior effect on the behavior of RC slabs with small openings (less than 2% opening ratio) compared to the acceptable improvements obtained for sabs with larger opening sizes. Consequently, PF could be utilized as a replacement for conventional steel rebars for RC slabs with small openings. In addition, increasing the PF percentage increases the resulting crack-opening value at failure due to the provided stabilization effect, in addition to increasing the system’s ability to sustain loads.