The structural proteome for the primordial glycolysis/gluconeogenesis

Ijb, do Ó; Tg, Rego; José, Marco V.; St, de Farias

doi:10.1101/706192

Cited by 1 publication

(2 citation statements)

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“…In this study, a structural distance tree was constructed, and the results indicated that ancestral structures were more similar to proteins found in ancestral families of viruses. Do Ó et al (2020 ) reconstructed the structure of translated proteins from ancestral tRNAs and observed similarities to proteins of the glycolytic pathway. The results presented by them indicated that the catalytic site must have been the first part to be structured.…”

Section: The Origin Of the First Genes And The Structuring Of Metabolismmentioning

confidence: 99%

“…First, we must acknowledge that it is a consensus among the specialists that the RNA molecules were the first informational molecules of life and that DNA appeared later. On that matters, many researchers are suggesting a late appearance of DNA at quasi-cellular stage on which most of the biochemical pathways were already assembled ( Forterre, 2005 ; Do Ó et al, 2020 ; Farias et al, 2021 b; Di Giulio, 2021 b). Two main facts strengthened the idea of the RNP world over the RNA world: (i) the abundance of amino acids in simulations of prebiotic environments and (ii) the understanding of the origin, importance, and evolution of ribosomes ( Belousoff et al, 2010 ; Farias et al , 2014 ; Petrov et al, 2015 ; Farias and José, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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RNP-world: The ultimate essence of life is a ribonucleoprotein process

Farías

Prosdocimi

2022

Genet. Mol. Biol.

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The fundamental essence of life is based on process of interaction between nucleic acids and proteins. In a prebiotic world, amino acids, peptides, ions, and other metabolites acted in protobiotic routes at the same time on which RNAs performed catalysis and self-replication. Nevertheless, it was only when nucleic acids and peptides started to interact together in an organized process that life emerged. First, the ignition was sparked with the formation of a Peptidyl Transferase Center (PTC), possibly by concatenation of proto-tRNAs. This molecule that would become the catalytic site of ribosomes started a process of self-organization that gave origin to a protoorganism named FUCA, a ribonucleic ribosomal-like apparatus capable to polymerize amino acids. In that sense, we review hypotheses about the origin and early evolution of the genetic code. Next, populations of open biological systems named progenotes were capable of accumulating and exchanging genetic material, producing the first genomes. Progenotes then evolved in two paths: some presented their own ribosomes and others used available ribosomes in the medium to translate their encoded information. At some point, two different types of organisms emerged from populations of progenotes: the ribosome-encoding organisms (cells) and the capsid-encoding organisms (viruses).

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Section: The Origin Of the First Genes And The Structuring Of Metabolismmentioning

confidence: 99%