The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

Abstract

Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures.

Triethylphosphinegold(I) Complexes with Secnidazole-Derived Thiosemicarbazones: Cytotoxic Activity against HCT-116 Colorectal Cancer Cells under Hypoxia Conditions

“…Hypoxia is frequently a characteristic of late-stage solid tumors. In solid tumor tissues, which grow and proliferate, oxygen consumption is higher than oxygen supply and transport, and the distance between cells and the abnormal vasculature increases, weakening oxygen circulation. , Hence, hypoxia-selective compounds may in principle exhibit anticancer effects with reduced systemic toxicity.…”