The Structure and Function of a Red Blood Cell in Health and Critical Conditions

Moroz, V. V.; Голубев, А. М; Афанасьев, А. В.; Kuzovlev, Аrtem; Сергунова, В. А.; Гудкова, О. Е.; Черныш, А. М.

doi:10.15360/1813-9779-2012-1-52

Cited by 28 publications

(17 citation statements)

References 8 publications

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“…The erythrocyte membrane is known to account for 1% of the total cell weight. It has high capacity of plasticity and flexibility and contains a number of membrane-bound enzymes required for glycolysis, the pentose phosphate cycle, ion-transport, and glutathione systems, as well as membrane-receptor complexes and antioxidants [63].…”

Section: Discussionmentioning

confidence: 99%

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Revin

Gromova

Revina

et al. 2019

BioMed Research International

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This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells and altered quantitative and qualitative composition of membrane-skeletal proteins. The findings suggest that hypoxia causes changes at all levels of red blood cell organization, which can cause the functional disorders of hemoglobin oxygen-transporting properties and, eventually, the complete degradation of red blood cells. The use of flavonoids has a protective effect against hypoxia.

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Section: Discussionmentioning

confidence: 99%

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Revin

Gromova

Revina

et al. 2019

BioMed Research International

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“…The erythrocytic mass was represented chiefly by cells of irregular shape ( Figure 2 a–d). According to Moroz et al [ 25 ], they are chiefly stomatocytes and echinocytes with few erythrocytes in their common morphology of biconcave discs. According to O’Connor [ 28 ], they are chiefly stomatocytes and echinocytes belong to degenerative forms.…”

Section: Resultsmentioning

confidence: 99%

“…Research into clinically significant biomarkers of septicemia have been commenced on and it has not yielded effective results yet; thus, there is need for investigations into this area. Despite emerging research on the ultrastructure of blood cells for adults in critical condition [ 25 ], there is lack of similar studies of children. The purpose of this study is to research the ultrastructure of blood cells in children in abdominal septic shock against the background of generalized purulent peritonitis of appendicular origin.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural Changes of Blood Cells in Children with Generalized Purulent Peritonitis: A Cross-Sectional and Prospective Study

et al. 2020

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In conditions of abdominal sepsis with indications of first- or second-stage shock, blood cells undergo significant ultrastructural changes that cause impaired gas exchange, changes in reactivity, and decompensation of organs and systems functions. This paper presents a cross-sectional prospective study aimed at researching the ultrastructure of blood cells in children experiencing abdominal septic shock against the background of generalized purulent peritonitis of appendicular origin. This study was conducted with 15 children aged 6–12 who were undergoing treatment for generalized appendicular purulent peritonitis, with first- or second-stage abdominal septic shock, in emergency care. The changes in the ultrastructure of erythrocytes did not correspond to changes characteristic of eryptosis, which confirms their occurrence under the influence of such pathogenic factors as intoxication, metabolic, water–electrolyte balance, and acid–base disorders. Ultrastructural changes of granulocytes indicate their hyperactivation, which leads to the exhaustion of membrane synthetic resources, membrane destruction, ineffective expenditure of bactericidal factors on substrates that are not subject to destruction. In lymphocytes, disorganization of the nuclear membrane and intracellular membranes, uneven distribution of chromatin, the hypertrophied Golgi apparatus, and a large number of young mitochondria, lysosomes, ribosomes, vesicles manifesting the disruption of metabolism, stress and decompensation of energy supply and protein synthesis systems, have been demonstrated. In conditions of abdominal sepsis with indications of first- or second-stage shock, blood cells undergo substantial ultrastructural changes causing gas exchange disruption, changes in reactivity, as well as decompensation of organs and system functioning.

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“…The decrease in the deformability of erythrocyte membrane also leads to poor oxygen exchange [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Study of the Structure, Oxygen-Transporting Functions, and Ionic Composition of Erythrocytes at Vascular Diseases

Ревин

Gromova

Revina

et al. 2015

BioMed Research International

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The present paper explores the role of erythrocytes in the pathogenesis of vascular diseases. The state of erythrocytes, their ionic composition and structure, and properties of erythrocytes hemoglobin were studied by using laser interference microscopy, Raman scattering spectroscopy, and capillary electrophoresis. In patients suffering from vascular disorders we identified statistically significant changes in the shape of erythrocytes, their ionic composition, and redistribution of hemoglobin throughout cells.

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The Structure and Function of a Red Blood Cell in Health and Critical Conditions

Cited by 28 publications

References 8 publications

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Ultrastructural Changes of Blood Cells in Children with Generalized Purulent Peritonitis: A Cross-Sectional and Prospective Study

Study of the Structure, Oxygen-Transporting Functions, and Ionic Composition of Erythrocytes at Vascular Diseases

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