The Structure and Function of the Glomerular Mesangium

Michielsen, Paul; Creemers, J

doi:10.1016/b978-1-4832-3097-9.50007-1

Cited by 23 publications

(6 citation statements)

References 15 publications

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“…Mes angial matrix is in direct continuity with the lacis cells of the juxtaglomerular apparatus. With this topographical relation in mind, the question can be raised whether the mesangial cells are not sensitive pressoreceptors, through their intracapillary pseudo podia, controlling the secretions of renin by the juxtaglomerular cells [10]. This hypothesis fits well with the findings in rickettsial disease, in which there is circulatory collapse and pseudopods of mesangial cells are more frequent.…”

Section: Commentssupporting

confidence: 74%

See 1 more Smart Citation

Glomerular Response in Human and Experimental Rickettsial Disease (Rocky Mountain Spotted Fever Group)

Brito¹,

Tiriba²,

Godoy³

et al. 1968

Pathobiology

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Section: Commentssupporting

confidence: 74%

“…Michielsen and Creemers [ 10]. among others, believe that they are modified smooth muscle cells and the glomerular capillaries should be considered as modified arterioles.…”

Section: Commentsmentioning

confidence: 99%

Glomerular Response in Human and Experimental Rickettsial Disease (Rocky Mountain Spotted Fever Group)

Brito¹,

Tiriba²,

Godoy³

et al. 1968

Pathobiology

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“…These experimental situations are characterized also by increased serum lipid levels [6,7,24], and fat is often present in FSGHS lesions in these situations [4,6,131. The possibility that the deposition of lipid plays an important role in the pathogenesis of FSGHS lesions is an attractive one when it is remembered that mesangial cells represent modified smooth muscle cells [19,25,261. It is well known from studies on the pathogenesis of atherosclerosis that the smooth muscle cell reacts with the incorporation of fat and deposition of different types of collagen and glycosaminoglycans to continuous exposure to cholesterol [27,28].…”

Section: Discussionmentioning

confidence: 99%

Mesangial function and glomerular sclerosis in rats after unilateral nephrectomy

Grond¹,

Schilthuis²,

Koudstaal³

et al. 1982

Kidney International

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To investigate the possible relationship between disturbance of mesangial function and segmental localization of glomerular sclerosis, five uninephrectomized male Wistar rats and five sham-operated controls received colloidal carbon intravenously. At 4 months 8.4 +/- 2.5% of the glomeruli of the nephrectomized rats showed focal sclerosis. Glomeruli of nephrectomized rats contained significantly more carbon than glomeruli of controls. Glomeruli with focal sclerosis contained significantly more carbon than normal glomeruli in the same kidneys with a preferential tracer localization within the lesions. In another experiment carbon injections were given before surgery. At 4 months 12.6 +/- 4.1% of the glomeruli of the nephrectomized rats showed focal sclerosis, an incidence not significantly different from that of the first experiment. Glomerular carbon content was equal in experimental and control rats and no preferential localization of the tracer within the lesions was found. From these results we conclude that the preferential localization of carbon in the glomerular lesions in rats nephrectomized before injection of carbon is caused by the increased delivery of tracer shortly after injection to those glomerular areas where sclerosis will develop at a later time. The development of focal sclerosis may be related to the local deposition of harmful substances from the circulation.

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“…Among the above-described mesangial structures few collagen fibrils with a typical period can also be detected, as observed by Latta [1961], In addition, fixation in the pres ence of alcian blue demonstrates a surface coat (presumably glycoproteins) associated with the outer leaflet of the mesangial cell plasma membrane. This is not surprising since the mesangial cells are considered as modified smooth muscle cells [see, for exam ple, Michielsen and Creemers, 1967], These cells display a surface coat which has been demonstrated in vascular smooth muscle cells by Wight and Ross [1975],…”

Section: Discussionmentioning

confidence: 99%

Glomerular Basement Membrane and Mesangial Matrix

Reale¹,

Luciano²,

Kühn³

et al. 1981

Kidney Blood Press Res

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Perfusion fixation of the rat kidneys with aldehydes and alcian blue demonstrates within the glomerular mesangium various components displaying anionic binding sites. These are the surface coat of the mesangial cells, numerous mesangial microfibrils (probably glycoproteins), and polygonal particles (presumably proteoglycans). These particles lie close to the mesangial cells and form assemblies of various extension within the mesangial matrix as well. In addition, a discontinuous basement membrane can be recognized which surrounds the mesangial cells. In the hagfish glomeruli (fixed without cationic dye), a prominent layer of microfibrils is interposed between mesangial and endothelial cells. Both these cells show incomplete basement membranes.

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The Structure and Function of the Glomerular Mesangium

Cited by 23 publications

References 15 publications

Glomerular Response in Human and Experimental Rickettsial Disease (Rocky Mountain Spotted Fever Group)

Glomerular Response in Human and Experimental Rickettsial Disease (Rocky Mountain Spotted Fever Group)

Mesangial function and glomerular sclerosis in rats after unilateral nephrectomy

Glomerular Basement Membrane and Mesangial Matrix

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