The structure and properties of some indolic constituents in Couroupita guianensis aubl

Bergman, Jan; Lindström, Jan-Olof; Tilstam, Ulf

doi:10.1016/s0040-4020(01)96609-8

Cited by 149 publications

(83 citation statements)

References 18 publications

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“…5 and in Couroupita guianensis Aubl. 6 , and has also been found as a component of the secretion from the parotid gland of Bufo frogs 7 , and in humans as it is a metabolic derivative of adrenaline [8][9][10] . Substituted isatins are also found in plants, for example the melosatin alkaloids (methoxy phenylpentyl isatins) obtained from the Caribbean tumorigenic plant Melochia tomentosa [11][12][13] as well as from fungi: 6-(3'-methylbuten-2'-yl)isatin was isolated from Streptomyces albus 14 and 5-(3'-methylbuten-2'-yl)isatin from Chaetomium globosum 15 .…”

Section: Introductionmentioning

confidence: 99%

The chemistry of isatins: a review from 1975 to 1999

Silva¹,

Garden²,

Pinto³

2001

J. Braz. Chem. Soc.

860

447

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Isatinas (1H-indol-2,3-diona) são compostos de grande versatilidade sintética, podendo ser utilizados na obtenção de diversos sistemas heterociclos, como derivados indólicos e quinolínicos, o que as tornam importantes matérias-primas na síntese de fármacos. Isatinas também têm sido detectadas em tecidos de mamíferos, o que tem despertado o interesse em seu estudo como moduladores em diversos processos bioquímicos. Os avanços na aplicação de isatinas em síntese orgânica, bem como na compreensão de seus efeitos biológicos e farmacológicos nos últimos vinte e cinco anos encontram-se relatados nesta revisão e seus respectivos materiais suplementares.Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis. Isatins have also been found in mammalian tissue and their function as a modulator of biochemical processes has been the subject of several discussions. The advances in the use of isatins for organic synthesis during the last twenty-five years, as well as a survey of its biological and pharmacological properties are reported in this review and in the accompanying supplementary information.

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Section: Introductionmentioning

confidence: 99%

The chemistry of isatins: a review from 1975 to 1999

Silva¹,

Garden²,

Pinto³

2001

J. Braz. Chem. Soc.

860

447

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show abstract

“…19 Isatin is present in the brain and other tissues in humans, and the oxindole moiety is also found in natural products in some plants. 20 The metabolism of isatin in humans is not yet well elucidated. It has been suggested that tryptophan and/or phenylalanine is converted by intestinal bacteria into indole, which is then absorbed and metabolized in the liver to isatin via 3-hydroxyindole.…”

Section: Oxindoles and Their Biological Activitiesmentioning

confidence: 99%

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

Cerchiaro

Ferreira

2006

J. Braz. Chem. Soc.

164

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Oxindóis são compostos endógenos encontrados em fluidos e tecidos de mamíferos. Particularmente, isatina (1H-indol-2,3-diona) e seus derivados vêm mostrando uma grande variedade de efeitos no meio biológico, incluindo a inibição de monoamina oxidase, atividade bactericida, fungicida, antiviral e antiproliferativa. Pesquisas mais recentes descrevem estes compostos como inibidores de quinases, uma classe de proteínas envolvidas em várias etapas do ciclo celular. Nesta revisão, complexos de cobre(II) com ligantes derivados de oxindóis são discutidos como potenciais agentes antitumorais, em comparação com outros complexos, com base na proposição de se aliar as propriedades redox e coordenativas do metal à capacidade de afetar os processos de angiogenese e apoptose já demonstrada por esse tipo de ligante.Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes.

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“…Leaves are used to make juice which is used to treat skin diseases, and South Americans use each part of the C. guianensis tree to treat malaria. The studies of chemical constituents show the presence of α-amirin, β-amirin, β-sitosterol, nerol, tryptanthrine, indigo, indirubin, isatin, linoleic acid, carotenoids, and sterols [3][4][5][6][7][8]. Singh et al [9] reported that aqueous extract of C. guianensis is endowed with flavonoids, alkaloids, phlorotannins, glycosides, tannins, steroids, and terpenoids.…”

Section: Introductionmentioning

confidence: 99%

Couroupita Guianensis: The Reservoir of Medicinal Compounds of Human Welfare

Moorthi

S²

2017

Asian J Pharm Clin Res

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Medicinal plants play a role in the traditional form of providing relief to several diseases. Couroupita guianensis is also a type of medicinal plant which has antibacterial, antimycobacterial, antimicrobial, antioxidant, antitumor, antiulcer, antinociceptive, anthelmintic, antifertility, and antifungal activities. The chemical constituent of C. guianensis such as indirubin serves as an antibacterial and antifungal agent because it particularly cures fungal diseases. It is active for the treatment of chronic myelocytic leukemia. The extract of isatin from the flower of C. guianensis is also a chemical component that has been used as prophylactic agent, prevents free radial-induced cancer, acts as a chemotherapeutic agent to kill cancer cells, and it has antioxidant (act as major defense) and anticancer activities against human promylocytic leukemia 60 cells. The extract of chloroform of fruit of C. guianensis shows good antimicrobial activity but low antimycobacterial activity. The plant extract of C. guianensis is equipotent to standard drugs such as paracetamol in its analgesic activity and indomethacin in its anti-inflammatory activity.

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The structure and properties of some indolic constituents in Couroupita guianensis aubl

Cited by 149 publications

References 18 publications

The chemistry of isatins: a review from 1975 to 1999

The chemistry of isatins: a review from 1975 to 1999

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

Couroupita Guianensis: The Reservoir of Medicinal Compounds of Human Welfare

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