The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum

Yang, Shuzhen; Zhou, Jie; Li, Dongmei; Shang, Chunyu; Peng, Liwei; Pan, Siyi

doi:10.1016/j.foodchem.2016.12.001

Cited by 21 publications

(15 citation statements)

References 32 publications

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“…However, this rationale should be further proven by comparing the MIC value of DMY with that of the analog whose structure differing only in without hydroxyl group at position 3 on the C-ring. Moreover, although a previous study has reported that the hydrogenation of C2=C3 bond reduces the antifungal activity of 5,7-dihydroxyflavonoids [4], we found that the MIC value of DMY was comparable to that of 4 with C2=C3 bond. Considering that compound 4 bearing C2=C3 bond possesses a nearly planar skeleton structure, it could be speculated that the stereoscopic configuration of DMY probably did not affect its antibacterial activity.…”

contrasting

confidence: 93%

Antibacterial Effect of 2R,3R-dihydromyricetin on the Cellular Functions of Staphylococcus aureus

Bai

et al. 2018

Bioscience, Biotechnology, and Biochemistry

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contrasting

confidence: 93%

Antibacterial Effect of 2R,3R-dihydromyricetin on the Cellular Functions of Staphylococcus aureus

Bai

et al. 2018

Bioscience, Biotechnology, and Biochemistry

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“…PIN has been described to cause inhibition of trihydroxinaphtalen reductase, described as a key enzyme on modern fungicidal drugs development [ 33 ]. NAR has been described to cause proton-motive force alterations in some strains [ 34 ], a result which is in agreement with that obtained by Peng et al.…”

Section: Resultsmentioning

confidence: 99%

Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts

Soberón

Sgariglia

Torrez

et al. 2020

Heliyon

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Tessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern Argentina for fungal infections treatment. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU), against Candida albicans strains. Two antifungal flavanones were identified as naringenin (NAR) and pinocembrin (PIN). These compounds could individually inhibit the growth of C. albicans strains. Combinations of NAR and PIN with FLU were synergistic against the FLU resistant and sensitive C. albicans strains. Genotoxic and cytotoxic evaluations were also performed. NAR, PIN and their combinations with FLU did not have a genotoxic effect on Bacillus subtilis rec strains. Finally, these compounds did not show cytotoxicity at concentrations below 80 μg/mL.

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“…and Phomopsis spp. (Gabaston et al, ; Peng et al, ; Quiroga, Sampietro, Soberón, Sgariglia, & Vattuone, ; Yang et al, ).…”

Section: Resultsunclassified

Antifungals from forest trees: Usefulness in the control of etiological agents of late season soybean diseases

Sequin

Sampietro

Gómez

et al. 2019

Annals of Applied Biology

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Septoria brown spot and Cercospora leaf blight are late season diseases caused by Septoria glycines and Cercospora kikuchii, respectively. New antifungals are required against these diseases because the chemical controls currently used have detrimental impacts on wildlife and human health. In this work, 48 extracts originated from the leaves, bark, sapwood or heartwood of four forestry species were assayed by the disc diffusion method against S. glycines and C. kikuchii.Although 18 extracts showed antifungal activity, only 5 were active on both fungal species. The leaf methanolic extract of Blepharocalyx salicifolius showed the lowest minimum inhibitory dose (MID) and the highest diameter of growth inhibition (DI) on both fungal species (MID = 200 μg, DI = 14.2 mm, C. kikuchii; MID = 400 μg, DI = 12.2 mm, S. glycines). Pinocembrin was identified as the main antifungal constituent of the methanolic extract. Both the methanolic leaf extract of B. salicifolius and pinocembrin synergized in vitro the effect of the fungicide difenoconazole.Preventive applications of the extract and the mixture extract + difenoconazole (2.4 mg/mL + 0.006 mg/mL) strongly reduced disease severity generated by S. glycines and C. kikuchii 21 days after inoculation of the soybean plants. This effect was significantly stronger than that generated by difenoconazole. Our results suggest that the application of the methanolic extract of B. salicifolius, alone or in mixture with difenoconazole is a promising strategy to be incorporated in the chemical control of S. glycines and C. kikuchii.

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The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum

Cited by 21 publications

References 32 publications

Antibacterial Effect of 2R,3R-dihydromyricetin on the Cellular Functions of Staphylococcus aureus

Antibacterial Effect of 2R,3R-dihydromyricetin on the Cellular Functions of Staphylococcus aureus

Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts

Antifungals from forest trees: Usefulness in the control of etiological agents of late season soybean diseases

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