The structure of a bioactive calcia–silica sol–gel glass

Skipper, Laura J.; Sowrey, Frank E.; Pickup, David M.; Drake, Kieran O.; Smith, Mark E.; Saravanapavan, Priya; Hench, Larry L.; Newport, Robert J.

doi:10.1039/b501496d

Cited by 64 publications

(104 citation statements)

References 26 publications

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“…In addition to studying the structure and corresponding early stages of dissolution (stages 1 and 2), complementary diffraction studies have been conducted characterizing the formation of the silica-rich layer followed by amorphous calcium phosphate and HCA (stages 3-5) [54,61]. FitzGerald et al [53] designed a sample cell that enables XRD patterns to be continually collected from a 70S30C foam reacting in SBF on a synchrotron beamline.…”

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

“…These techniques require major national/international facilities but can provide detailed information on glass structure. Conventional XRD, high-energy X-ray diffraction [53] and ND [54,55] measure the total diffraction pattern. It can sometimes be difficult to determine individual correlations from a single diffraction pattern owing to the overlapping correlation functions.…”

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

“…To probe the Ca-O environment in 70S30C glass, the method of isotopic substitution applied to ND was employed [54,55]. Two 70S30C samples were prepared, both deuterated to avoid inelastic scattering from hydrogen: one sample contained naturally abundant calcium, whereas the second sample contained enriched 44 Ca.…”

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

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Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Martin

Sheng

Hanna

et al. 2012

Phil. Trans. R. Soc. A.

122

106

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Bone is the second most widely transplanted tissue after blood. Synthetic alternatives are needed that can reduce the need for transplants and regenerate bone by acting as active temporary templates for bone growth. Bioactive glasses are one of the most promising bone replacement/regeneration materials because they bond to existing bone, are degradable and stimulate new bone growth by the action of their dissolution products on cells. Sol-gel-derived bioactive glasses can be foamed to produce interconnected macropores suitable for tissue ingrowth, particularly cell migration and vascularization and cell penetration. The scaffolds fulfil many of the criteria of an ideal synthetic bone graft, but are not suitable for all bone defect sites because they are brittle. One strategy for improving toughness of the scaffolds without losing their other beneficial properties is to synthesize inorganic/organic hybrids. These hybrids have polymers introduced into the sol-gel process so that the organic and inorganic components interact at the molecular level, providing control over mechanical properties and degradation rates. However, a full understanding of how each feature or property of the glass and hybrid scaffolds affects cellular response is needed to optimize the materials and ensure long-term success and clinical products. This review focuses on the techniques that have been developed for characterizing the hierarchical structures of sol-gel glasses and hybrids, from atomicscale amorphous networks, through the covalent bonding between components in hybrids and nanoporosity, to quantifying open macroporous networks of the scaffolds. Methods for non-destructive in situ monitoring of degradation and bioactivity mechanisms of the materials are also included.

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Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

See 1 more Smart Citation

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Martin

Sheng

Hanna

et al. 2012

Phil. Trans. R. Soc. A.

122

106

View full text Add to dashboard Cite

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“…Synchrotron-based X-ray diffraction (XRD), for example, can show details about both crystalline phases and local atomic arrangement that conventional XRD cannot pick up, because of the higher flux and lower wavelength of exciting X-rays used. Jones & Skipper applied this technique to analyse the transformation of silicate bioceramics in SBF [84,109]; they showed Ca 2+ ions being continuously released and re-deposited on the material surface, and the formation of an octacalcium phosphate layer, followed by an amorphous layer that only after several hours crystallized into HCA ( figure 13). These results thus showed that surface reactions on these materials are more complex than originally hypothesized.…”

Section: (C) Synchrotron-based Techniquesmentioning

confidence: 99%

Surface characterization of silicate bioceramics

Cerruti

2012

Phil. Trans. R. Soc. A.

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The success of an implanted prosthetic material is determined by the early events occurring at the interface between the material and the body. These events depend on many surface properties, with the main ones including the surface's composition, porosity, roughness, topography, charge, functional groups and exposed area. This review will portray how our understanding of the surface reactivity of silicate bioceramics has emerged and evolved in the past four decades, owing to the adoption of many complementary surface characterization tools. The review is organized in sections dedicated to a specific surface property, each describing how the property influences the body's response to the material, and the tools that have been adopted to analyse it. The final section introduces the techniques that have yet to be applied extensively to silicate bioceramics, and the information that they could provide.

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“…Under physiological conditions bioactive glasses dissolve in a controlled manner releasing calcium and phosphorous into solution. Ca and P form an amorphous calcium phosphate layer (ACP) which then crystallizes to form hydroxyapatite (HA) / Hydroxyl-carbonate apatite (HCA) [3,4] : the naturally occurring mineral present in both teeth and bones.…”

Section: Introductionmentioning

confidence: 99%

In vitro bioactivity of titanium-doped bioglass

Asif

Shelton

Cooper

et al. 2014

J Mater Sci: Mater Med

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Previous studies have suggested that incorporating small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigates the in vitro bioactivity of a titanium doped bioglass and compares the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

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The structure of a bioactive calcia–silica sol–gel glass

Abstract: The version in the Kent Academic Repository may differ from the final published version. Users are advised to check http://kar.kent.ac.uk for the status of the paper. Users should always cite the published version of record.

Cited by 64 publications

References 26 publications

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Surface characterization of silicate bioceramics

In vitro bioactivity of titanium-doped bioglass

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