The structure of bongkrekic acid

Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis

“…HL-60 cells were pre-treated as described with either 0.1% (v/v) DMSO or 100 mM z-VAD-fmk prior to addition of 70 mM etoposide. Western blots were preformed as described in Materials and methods on gels containing either mitochondrial fraction (a), or cytosolic fraction (b) were also pre-incubated for 30 min with either 1 mM cyclosporin A (CyA) dissolved in ethanol or 50 mM bongkrekic acid (BA;Lijmbach et al, 1970;de Bruijn et al, 1973), dissolved in 1.6 mM NH 4 OH. Peptide caspase inhibitors were used as described elsewhere .…”

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

“…The carrier cycles between the cytoplasmic-open state (c-state), which can be trapped by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) ( Vignais et al., 1973 ), and the matrix-open state (m-state), which is locked by the membrane-permeable bongkrekic acid (BKA) ( Erdelt et al., 1972 , Henderson and Lardy, 1970 ). BKA is a polyunsaturated methoxy tricarboxylic acid polyketide produced by Burkholderia gladioli pathological variant cocovenenans ( de Bruijn et al., 1973 , van Veen and Mertens, 1934 ). Over 2,000 cases of human fatality from BKA poisoning have been reported in Indonesia, China, and Mozambique since 1950, due to contamination of corn or coconut products ( tempe bongkrek ) ( Anwar et al., 2017 , Falconer et al., 2017 ).…”

Terminating catalytic asymmetric Heck cyclizations by stereoselective intramolecular capture of η3-allylpalladium intermediates: total synthesis of (−)-spirotryprostatin B and three stereoisomers

“…24,25 Trimethylaluminum-mediated conversion of ester 21 to anilide 22 proceeded smoothly in 80% yield 26. Protection of the resulting amide nitrogen with SEM-Cl afforded ( E )-2,4-hexadienamide substrate 23 in good overall yield.…”