We refine Theorem B due to Gursky [26]. As applications, we give some rigidity theorems on four-manifolds with postive Yamabe constant. In particular, these rigidity theorems are sharp for our conditions have the additional properties of being sharp. By this we mean that we can precisely characterize the case of equality. We prove some classification theorems of four manifolds according to some conformal invariants (see Theorems 5.1, 1.3 and 1.6), which reprove and generalize the conformally invariant sphere theorem of Chang-Gursky-Yang [11], i.e., Theorem D.2000 Mathematics Subject Classification. Primary 53C21; Secondary 53C20.